This $317,533 federal Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) aims to develop a mathematical model that can explain the heterogeneity in how yeast cells transition between proliferation and quiescence in response to various stress stimuli. The award to North Carolina State University will leverage novel deep learning techniques to directly learn differential equation models from single-cell protein expression data....
The National Science Foundation awarded New York University a $120,000 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop a mathematical model of mitosis. The award period is from June 15, 2022 to May 31, 2026. Under the award, NYU will build on previous work modeling cell division to create a more realistic simulation of closed mitosis. Researchers will extend their model to include a deformable elastic nuclear envelope integrating the...
This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
This three-year, $719,144 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research at Rensselaer Polytechnic Institute to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The framework will use statistical summaries and parameterization through in vitro experiments to model crosslinker-mediated interactions between microtubules during cell division. Researchers will construct a reduced...
This $1.2 million National Science Foundation project grant, awarded under the Biological Sciences program (CFDA 47.074), will fund research at the University of North Carolina at Chapel Hill from March 2023 through February 2027 toward developing a revised model of the cell cycle that captures reversible and irreversible cell cycle arrest. The principal investigator will define the molecular mechanisms governing the transition between reversible quiescence and irreversible senescence, as well...
This $592,495 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) will support research at Dartmouth College from February 15, 2023 to January 31, 2025. The project aims to identify the molecular pathway controlling meiotic termination in budding yeast through experiments analyzing how autophagy shapes the meiotic transcriptome and proteome at different stages of meiosis. Researchers will define...
This $1,269,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular basis of how plant cells establish the division plane during cell division. The project aims to dissect the function of cytoskeletal motor assemblies at the cortical division site and determine how they connect to molecules in the phragmoplast, the structure that forms the new cell wall during cytokinesis. Researchers at...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will...
The National Science Foundation awarded a $1,715,342 project grant to The Regents of the University of California, San Francisco under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 through July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this osmotic model of...
This Project Grant award of $136,600 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at William Marsh Rice University to develop advanced tools for directly visualizing, quantifying, and correlating DNA dynamics, organization, and gene activity in real-time. The project aims to overcome challenges in studying these essential processes for regulating gene expression and healthy cell function, which have been implicated in various diseases. The...
This $185,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports fundamental research on the spatial-temporal orchestration of the START transition in budding yeast cells. The research aims to elucidate the molecular mechanisms that control the timing and synchrony of the G1/S transition, which is critical for regulating cell size and fitness. The work will employ experimental and modeling approaches to investigate the clustering patterns and temporal dynamics of the G1/S transcription factors. Findings from this project are expected to provide insights into the coordination of transcriptional programs responsible for cell state transitions, with potential applications in understanding human diseases related to cell size regulation. The grant recipient, Rensselaer Polytechnic Institute, will also incorporate multiple levels of training and outreach activities, including opportunities for high school, undergraduate, and graduate students, to promote equity in STEM education and research.