Project Grant 2348680
- This National Science Foundation (NSF) Biological Sciences grant award provides $2,225,964 to the Georgia Tech Research Corporation (Georgia Tech) to develop a novel biosensing platform called "protocell communities" that can be used for rapid, low-cost medical diagnostics. The project aims to create a tool that can diagnose medical conditions by detecting and integrating multiple indicator molecules, addressing limitations of single-analyte diagnostics. The protocell technology uses...
- Cornell University received a $100,000 Project Grant award from the National Science Foundation's Technology, Innovation, and Partnerships program to develop a cell-free biosensing platform integrating transmembrane proteins. The award period is from July 1, 2022 to December 31, 2022. Specifically, the university will utilize recent advances in biotechnology and bioelectronics to establish a process for rapidly assembling customized transmembrane proteins into a biomimetic sensing device without...
- The National Science Foundation (NSF) awarded a three-year, $449,999 Project Grant under their Engineering program (CFDA 47.041) to the University of Cincinnati to develop an implantable biosensor platform that can continuously monitor various biomarkers in the body for over a year. The project aims to create a new class of long-lasting aptamer-based sensors protected by robust porous oxide coatings, which would enable the first practical implantable monitoring system for managing chronic...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $500,000 in funding to The Regents of the University of Colorado to develop a suite of fluorescent RNA-based biosensors for monitoring metabolites in the methionine cycle of one-carbon metabolism in live cells. The project aims to create a "plug-and-play" toolkit of biosensors that can be used to study the dynamics and flux of central metabolites involved in regulating...
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $350,000 under the Biological Sciences program (CFDA 47.074) to Trustees of Tufts College for the TOOLS4CELLS project, effective August 1, 2025, through July 31, 2026. This Project Grant supports the development of turn-on biosensors (TOBS)—a novel measurement technology enabling real-time detection of endogenous biomolecules in live cells. The primary deliverable is the...
- The National Science Foundation (NSF) awarded a $568,480 Project Grant under the Engineering (CFDA 47.041) program to The Regents of the University of Colorado, doing business as the University of Colorado, to conduct research on a novel biosensing concept for high-sensitivity measurement of cell mechanical biomarkers. The 3-year award, effective May 1, 2024, will investigate how biological cells with different mechanical properties interact with acoustic waves propagating along a substrate, and...
- This $475,670 CAREER Project Grant awarded by the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) aims to develop a new method for tracking molecular changes in live tissue over time. The project will focus on creating a nanostructure-based system to continuously monitor cellular activity and interactions, which can help improve understanding of cellular behavior and advance medical treatments, particularly for complex...
- This $125,805 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies that can identify and separate cells based on changes in the activity of naturally occurring light-emitting molecules like NAD(P)H. The goal is to enable label-free, rapid identification and purification of cell populations, with a focus on stem cells and their functional subsets. The research will create a single cell deposition module to...
- This National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) Federal Grant Program (CFDA 47.070) award of $1,200,000 provides funding to the University of California, Berkeley from October 1, 2024 to September 30, 2028 to develop innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics for next-generation diagnostics. The key objectives of this project grant are to: (1) develop molecular engineering techniques using DNA origami...
- The National Science Foundation awarded Integrated Medical Sensors Inc. a $256,000 Project Grant under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a novel multi-analyte microsensor platform for continuous wireless monitoring applications. The grant aims to create a unique monolithic semiconductor platform capable of wirelessly monitoring multiple biochemical and physiological markers simultaneously in a sub-cubic millimeter footprint. This miniature,...
TUBULAR CELLULAR BIOSENSORS -LAYERED CELLULAR TUBES WIDELY OCCUR IN BIOLOGICAL SYSTEMS AND THE HUMAN BODY, RANGING FROM TINY BLOOD VESSELS TO MAMMARY DUCTS, AND THESE ARE ESSENTIAL FOR THE EFFICIENT DELIVERY OF SUBSTRATES, SECRETORY, AND EXCRETORY PRODUCTS IN MULTI-TISSUE SYSTEMS. THIS PROJECT AIMS TO DESIGN, FABRICATE, MODEL, AND VALIDATE TUBULAR BIOSENSORS TO PROBE THE BEHAVIOR OF CELLS IN TUBES WITH ANATOMICALLY RELEVANT DESIGN. THE PROJECT ADVANCES BIOSENSORS FROM INHERENTLY PLANAR TO TUBULAR AND CURVED ENVIRONMENTS. IT WILL ALLOW THE SYSTEMATIC STUDY OF THE INDIVIDUAL AND COMBINATORIAL IMPACT OF BIOCHEMICAL STIMULI, LOCAL CURVATURE, AND STIFFNESS ON THE FUNCTION OF LIVE CELLS IN TUBULAR ENVIRONMENTS. INSIGHTS FROM THIS WORK WILL BE USEFUL IN DIVERSE FIELDS, INCLUDING IN SITU BIOSENSOR DESIGN FOR REAL-TIME MEASUREMENTS IN LIVING SYSTEMS, BIOFILMS, AND ORGAN-ON-CHIP MODELS OF ENVIRONMENTAL EXPOSURES AND DISEASE MODELING. STRAIN PRODUCED BY CURVATURE HAS A PRONOUNCED EFFECT ON CELLULAR BEHAVIOR, AND FLUID FLOW CAN BE SIGNIFICANTLY DIFFERENT IN TUBES WITH RECTANGULAR VS. CIRCULAR CROSS-SECTIONS. HENCE, DEVELOPING TISSUE-ENGINEERED MODELS FOR TUBULAR DUCTS, ESPECIALLY AT SUB-MILLIMETER DIAMETERS, IS A CRITICAL YET UNMET CHALLENGE IN CELL BIOLOGY AND BIOENGINEERING. THIS PROPOSAL AIMS TO COMBINE BIOSENSOR INTEGRATION AND CELL BIOLOGY EXPERTISE TO CREATE ANATOMICALLY RELEVANT TUBULAR CELLULAR BIOSENSORS WITH TUNABLE DIMENSIONS AND CELLULAR CHARACTERISTICS. COMPLEX AND ANATOMICALLY RELEVANT CELL-LADEN TUBES WILL BE MASS-PRODUCED USING ACCURATE ALIGNMENT AND LAYERING OF CELLS AND MATRIX, ALONG WITH FUNCTIONAL BIOSENSORS BASED ON ELECTRICAL READOUTS. TUBULAR AND CURVED INTEGRATED ELECTROANALYTICAL SENSORS INCLUDE ELECTROCHEMICAL AND BIOCHEMICAL SENSORS THAT MEASURE THE EFFECTS OF THE PHYSICAL AND CHEMICAL VARIABLES ON CELLULAR FUNCTION. NEW INTEGRATED BIOSENSOR PLATFORMS WILL BE DEVELOPED AS MODEL SYSTEMS TO INTERROGATE CELL BEHAVIOR IN RESPONSE TO BIOCHEMICAL STIMULI IN ANATOMICALLY RELEVANT MICROENVIRONMENTS. STUDIES WILL INCLUDE COMPARISONS OF CELL FUNCTION IN VARYING CURVATURE VS. PLANAR GEOMETRIES, WHICH IS VITAL FOR ADDRESSING UNANSWERED QUESTIONS ON THE ROLE OF GEOMETRY IN THE MICROENVIRONMENT ON FUNDAMENTAL CELL BIOLOGY AND BIOMEDICAL ENGINEERING. THE BROADER IMPACTS OF THE PROPOSAL INCLUDE INTEGRATING PRINCIPLES OF 3D BIOSENSOR INTEGRATION AND THE EFFECT OF GEOMETRY ON LIVING SYSTEMS INTO EDUCATIONAL CURRICULA AND K-12, UNDERGRADUATE AND GRADUATE STEM TRAINING, AND RESEARCH EXPERIENCES. THESE EFFORTS WILL ENHANCE INTERDISCIPLINARY COOPERATIVITY AMONG THE POOLS OF ENGINEERING, BIOLOGY, CHEMISTRY, AND MEDICINE TRAINEES THAT THE PI?S INTERFACE WITH AND SERVE AS A TEMPLATE FOR CATALYZING INVESTIGATION AND INNOVATION ON THESE TOPICS THROUGH REGIONAL, NATIONAL, AND INTERNATIONAL SCIENTIFIC FORUMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $153.9k | 9/2/25 | ||
| Not listed | $319.1k | 4/9/24 |