This National Science Foundation (NSF) Biological Sciences grant award provides $2,225,964 to the Georgia Tech Research Corporation (Georgia Tech) to develop a novel biosensing platform called "protocell communities" that can be used for rapid, low-cost medical diagnostics. The project aims to create a tool that can diagnose medical conditions by detecting and integrating multiple indicator molecules, addressing limitations of single-analyte diagnostics. The protocell technology uses cell-free gene expression in aqueous droplets to sense target molecules and communicate with a central "receiver" protocell that integrates the signals to provide a diagnostic readout. This modular approach allows the platform to be easily adapted for different medical conditions. The project also includes efforts to enhance the efficiency and robustness of the protocell system for field use, with a focus on addressing zinc deficiency, a major global health challenge. In addition to the medical diagnostic applications, the project explores environmental applications of the proposed platform. The work is expected to have broad societal impact by improving access to diagnostics, particularly in underserved areas.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.2m | 8/7/23 |