This National Science Foundation (NSF) Project Grant under CFDA Number 47.041 - Engineering provides $360,000 in funding to Cornell University from July 1, 2023 to June 30, 2026 to develop a novel biosensing platform for the simultaneous detection and quantification of exosomes (small vesicles released from cells) and their molecular cargo. The key objectives are to: (1) develop methods to capture, quantify, and profile exosomes using a plasmonic biosensor; (2) develop techniques to lyse the...
Cornell University was awarded a $1,000,000 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences to support research titled "Engineering Photosensory Proteins Through the Better Understanding and Control of Proton-Coupled Electron Transfer Reactions." The award period is from August 1, 2021 through July 31, 2025. The grant funding will support basic research conducted under the Biological Sciences program (CFDA 47.074) to advance...
This $1.8 million project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Cornell University to develop single molecule tools and techniques for studying coronavirus membrane fusion. The goal is to understand the relationship between coronavirus fusion peptide sequence and target host cell membranes at the nanoscale. Specifically, the awardee will identify and measure the physicochemical interactions between the coronavirus spike...
This National Science Foundation (NSF) Biological Sciences grant award provides $2,225,964 to the Georgia Tech Research Corporation (Georgia Tech) to develop a novel biosensing platform called "protocell communities" that can be used for rapid, low-cost medical diagnostics. The project aims to create a tool that can diagnose medical conditions by detecting and integrating multiple indicator molecules, addressing limitations of single-analyte diagnostics. The protocell technology uses...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $429,656.00 to Cornell University to conduct research using synthetic biology methods to engineer microorganisms to produce valuable plant natural products. The key objectives are to reconstitute plant biosynthetic machinery in yeast in order to better understand and harness plant enzyme complexes for natural product synthesis. This research aims to develop a more resilient...
Cornell University was awarded a $1,317,788 project grant from the National Science Foundation Division of Integrative Organismal Systems to develop tools for host-microbiome protein-protein interaction discovery and establish sequencing-compatible ultra-high-throughput experimental screening approaches. The grant also supports the launch of annual bioinformatics hackathons for students centered on protein structure-inspired projects and the development of computational tools to assign...
This $228,697 National Science Foundation award under the Engineering program (CFDA 47.041) will support the development of an optical biosensor technology to facilitate drug screening and validation efforts. Auctus Biologics, Inc. will utilize a proprietary temperature, pH, and chemically stable protein composed of two fragments that bind with antibody-like affinity and specificity. Over the one-year period ending January 2023, the company will establish the technology's suitability for...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) is focused on developing an affordable, portable virus detection platform. The $331,189 project, awarded on April 1, 2025 and running through March 31, 2028, integrates protein engineering and electrochemical biosensor technologies to create a virus detection system that can operate in resource-limited environments. The innovation lies in using stable...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $230,000 to Cornell University, granted on March 15, 2025, supports research to characterize the protein-protein interactions and protein localization processes that drive the development of the stinging apparatus in cnidarian nematocytes (stinging cells). The overarching goal is to develop a framework for predicting the emergence of novel traits from novel protein-coding genes by investigating the...
This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...