Project Grant 2346165
- This $1,079,254 National Science Foundation project grant supports research investigating mechanisms of RNA polymerase II transcription and regulation using single molecule fluorescence techniques at the University of Colorado Boulder from March 2023 through February 2027. The research will study the assembly and disassembly of key protein complexes involved in early transcription stages using microscopy to observe individual molecules. Specifically, the research will investigate how the human...
- The University of Alabama at Birmingham (UAB) was awarded a 5-year, $400,000 CAREER project grant by the National Science Foundation (NSF) Integrative Activities (IA) program, effective February 1, 2024. This grant will support UAB's research to characterize the conformational dynamics of telomeric DNA, RNA, and DNA-RNA hybrid complexes using single-molecule techniques. The goal is to understand how the folding process of non-canonical DNA/RNA structures affects telomere maintenance and...
- This $363,800 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by The Johns Hopkins University investigating how supercoiled DNA impacts transcription, a core process of life that converts genetic information into RNA. The research will: Characterize how supercoiling affects transcription kinetics and correlation using in vitro single-molecule imaging of purified proteins and DNA constructs. Determine how chromosomal...
- The National Science Foundation (NSF) awarded a $649,905 Project Grant to the University of Chicago under the Mathematical and Physical Sciences program (CFDA 47.049) to study the evolutionary origin of kinetic proofreading, a mechanism that increases biochemical accuracy while consuming energy. The research team will develop a novel experimental platform to rapidly study the speed and accuracy of 1,000s of mutants of DNA polymerases, the molecular machines that copy genetic information. This...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $800,000.00 aims to dramatically expand the understanding of RNA modification enzymes (RMEs) - a class of proteins that chemically alter RNA molecules and influence their function, stability, and therapeutic potential. The project will systematically identify and assay over 750 RMEs from nearly 100 microbial organisms to establish foundational knowledge and resources to...
- The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $1,050,000 Project Grant to Princeton University to deepen the understanding of chemical modifications on ribonucleic acid (RNA) and their role in biological processes. The 3-year project, titled "Illuminating the Dihydrouridine Epitranscriptome," aims to characterize the RNA modification dihydrouridine (D) and its writer enzymes, as well as elucidate their biological function...
- This federal Project Grant award, valued at $541,574.00 and awarded on January 15, 2025, is funded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program. The project, titled "COLLABORATIVE RESEARCH: NSF/MCB-BSF: THE EFFECT OF TRANSCRIPTION FACTOR BINDING ON UV LESION ACCUMULATION", aims to determine whether transcription factor binding to DNA makes it more susceptible to damage or impedes DNA repair, leading to increased genomic...
This $930,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) is focused on advancing the understanding of transcription fidelity mechanisms in eukaryotic RNA polymerases. The project at the University of Alabama at Birmingham (UAB) will employ transient state kinetic approaches to quantify the differences in transcription and error correction mechanisms across the three eukaryotic RNA polymerases (I, II, and III). This research aims to fill a fundamental gap in the scientific community's knowledge of how higher organisms have evolved specialized enzymes for transcribing specific gene classes, compared to the single RNA polymerase used in prokaryotes. The project will train graduate students and undergraduates in rigorous biophysical research methods, enabling them to be more competitive for STEM careers. By gaining a deeper understanding of the chemical processes underlying high-fidelity gene expression, this research is expected to benefit a wide range of scientific fields and applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $930.0k | 7/8/24 |