This $930,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) is focused on advancing the understanding of transcription fidelity mechanisms in eukaryotic RNA polymerases. The project at the University of Alabama at Birmingham (UAB) will employ transient state kinetic approaches to quantify the differences in transcription and error correction mechanisms across the three eukaryotic RNA polymerases (I, II, and III). This research aims...
This $400,546 Project Grant was awarded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program. The funding will support a collaborative research project between investigators at the University of California, Irvine (UCI) and partners in Switzerland to use a rapid gene evolution system called Orthogonal DNA Replication (OrthoRep) to prospectively evolve simple artificial metalloenzymes into advanced biological enzymes. The goal is to understand how enzymes...
This National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) project grant award of $1,500,000 supports research by Dr. Tamar Schlick of New York University and Dr. Alain Laederach of the University of North Carolina at Chapel Hill. The project aims to develop advanced computational tools to predict and control how viral protein synthesis is affected by programmed ribosomal frameshifting (PRF) - the mechanism by which viruses and human cells modify gene expression. Key...
This $303,254 Project Grant from the National Science Foundation's Division of Environmental Biology, under the Biological Sciences program (CFDA 47.074), will fund research exploring the idea that the earliest adaptive evolution occurred through self-amplifying cycles of chemical reactions, rather than nucleic acids. Over a three-year period from August 2022 to July 2025, Michigan State University will conduct theoretical and laboratory studies to analyze how mixtures of chemicals could...
The Foundation For Applied Molecular Evolution, Inc. received a $426,000 Project Grant award from the National Science Foundation Division of Chemistry on August 15, 2021 to support research exploring the diverse evolutionary power of nucleic acid libraries carrying different information content. The three-year award, scheduled for completion on July 31, 2024, will fund work under the Mathematical and Physical Sciences program (CFDA 47.049). This program aims to promote progress in the...
The University of Chicago will receive $899,998 from the National Science Foundation under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) for a project grant award titled "Nonenzymatic RNA Replication." Professor Jack W. Szostak of Massachusetts General Hospital and Harvard University will lead research studying prebiotic chemistry relevant to the origin of life on Earth, focusing on how primordial RNA molecules could have replicated without enzymes. The...
The National Science Foundation Division of Environmental Biology awarded a $1,126,538 project grant to the University of Wisconsin-Madison under the Biological Sciences federal grant program (CFDA 47.074) to support research exploring the origin of life through ecological dynamics and adaptive evolution. Over a three-year period from August 2022 to July 2025, the university will conduct both theoretical and laboratory research to test the hypothesis that the earliest adaptive evolution occurred...
The federal Project Grant award, valued at $697,510.00 and funded by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program, aims to improve, validate, and interpret amino acid substitution models for protein evolution. The research will enhance understanding of how substitutions of amino acids in proteins impact their form and function, which is critical for reconstructing the evolutionary history of proteins and advancing phylogenetic inference. The project, with a...
This $262,588 National Science Foundation Project Grant under the Geosciences program (CFDA 47.050) will support research into prebiotic chemistry processes relevant to the origin of life on Earth. The Foundation For Applied Molecular Evolution, Inc. will use the funding to advance scientific understanding of geological environments on Earth 4.35 billion years ago that could have facilitated the emergence of the first genetic molecules. Key deliverables include completing structural analysis...
The National Science Foundation (NSF) Division of Environmental Biology awarded a $229,210 EAGER (Early-concept Grants for Exploratory Research) project grant to the University of Mississippi. The grant titled "Surveying Impacts of Community Context on Adaptive Mutational Landscapes" will run from September 1, 2023 to August 31, 2025. The project aims to examine how community context alters species evolution using new techniques in whole-genome analyses. It will bridge the fields of...