This $563,387 project grant was awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to the University of Mississippi. The grant is funding research to characterize the function of an unknown protein, BRESU_2828, that is found in many bacterial species, including some that are pathogenic to humans and crops. The project aims to investigate how this protein influences the synthesis of bacterial pili, which are surface structures used for attachment and...
This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $2,082,834 to The Ohio State University for research on bacterial genome engineering mechanisms. The university will study the interactions between the Red-Beta recombinase enzyme and single-stranded DNA binding protein in bacteria, using x-ray crystallography and cryo-electron microscopy to determine the three-dimensional...
This $543,105 federal Project Grant awarded by the National Science Foundation (NSF) under its Engineering program (CFDA 47.041) aims to investigate an approach for creating an optimized ribosome system to efficiently produce designer proteins. The key objective is to construct a ribosome that is hardwired to synthesize a specific protein by incorporating the genetic message directly into the ribosome structure. This "iRibo-T" system is expected to isolate the ribosome from normal...
The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a $299,983 Project Grant to North Carolina State University (NCSU) under the agency's Biological Sciences program (CFDA 47.074). The objective of this 2-year grant is to develop a new biotechnology called RIBOPI that will enable efficient, scalable, and cost-effective quantification of gene-specific translation regulation. RIBOPI aims to make translation regulation analysis as accessible as RNA sequencing...
The National Science Foundation awarded a $138,000 Project Grant to support research titled "Understanding Protein Synthesis in Energetically Constrained Microbial Consortia" from September 1, 2021 through August 31, 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074) to further the program's goals of advancing the biological sciences and strengthening the scientific enterprise through increased knowledge and understanding of major issues facing the...
This $526,831 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will investigate how the conserved, developmentally regulated GTP-binding protein DRG promotes protein synthesis when translating ribosomes slow down in bacterial and eukaryotic cells. The study aims to provide mechanistic insights into DRG-mediated functions in translation through in vitro biochemical experiments using reconstituted translation systems from E. coli and S....
The Ohio State University was awarded a $988,596 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant will support research from August 1, 2021 to July 31, 2025 on the structural dynamics and function of proteins using nuclear magnetic resonance spectroscopy and computational methods. The Biological Sciences program aims to advance the field and strengthen the national...
This federal Project Grant award, valued at $594,674.00 and granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the mechanisms of outer membrane biogenesis in gram-negative bacteria. The primary awardee, The Ohio State University, will leverage its expertise in genetic and biochemical approaches to study the cell envelope of Escherichia coli. The research aims to...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $629,896 Project Grant to the University of Wisconsin-Madison on February 15, 2021 with a completion date of January 31, 2026. The grant supports research under the Biological Sciences program (CFDA 47.074) to advance understanding of heterogeneous decision-making in individual microbes and populations through synthetic approaches. As the official program description indicates, the Biological Sciences...
This $461,575 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports research investigating how soil-dwelling bacteria recognize and protect themselves from toxic D-amino acids. The project will characterize the function of the bacterial enzyme ProXP-X, which uniquely binds both L- and D-amino acids, to understand how it prevents D-amino acid incorporation into bacterial proteins. Key research activities include using kinetic...