This $234,063 National Science Foundation (NSF) project grant, awarded under the NSF Engineering program (CFDA 47.041), seeks to engineer plants to produce enhanced therapeutic proteins and improve protein production performance. The key objectives are to: 1) investigate the glycosylation and functions of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins (GPI-APs) engineered in plant cells; 2) assess the broader applicability and potential applications of GPI-APs in plant cells; and 3) engineer GPI-APs to improve existing plant cell lines for enhanced protein production. The project, led by Arkansas State University, will leverage the unique GPI anchor structure to promote intracellular trafficking, homogeneous glycosylation, and surface display of therapeutic proteins in plant cells. This may increase the bioavailability of orally administered biopharmaceuticals derived from plants. The project will also provide hands-on learning opportunities for graduate and undergraduate students and outreach to regional K-12 students to foster interest in science and technology. No subwards are planned for this award, which has a performance period from July 1, 2024 to June 30, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $234.1k | 7/10/24 |