Project Grant 2402422

Award Date 7/1/24
Completion Date 6/30/27
Dollars Obligated $234K
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Jonesboro, AR 72401, USA
Similar Awards
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $429,656.00 to Cornell University to conduct research using synthetic biology methods to engineer microorganisms to produce valuable plant natural products. The key objectives are to reconstitute plant biosynthetic machinery in yeast in order to better understand and harness plant enzyme complexes for natural product synthesis. This research aims to develop a more resilient...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award provides $497,039 to Valdosta State University to investigate the biochemical mechanisms by which reactive oxygen species activate the GCN2 protein kinase and its role in regulating protein synthesis in Arabidopsis thaliana as a model plant system. The research aims to enhance understanding of plant stress responses and translational control mechanisms, which could contribute to developing...
This $377,731 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports machine learning and multi-omics network approaches to predict protein functions in the model plant system Arabidopsis. The research aims to employ artificial intelligence (AI) and deep learning to integrate diverse biological datasets and improve gene functional annotations, as well as predict functions for unclassified genes. The project will validate...
Colorado State University will provide research, education, and outreach services under a $622,699 Project Grant from the National Science Foundation Division of Integrative Organismal Systems. The grant falls under the NSF Biological Sciences program (CFDA 47.074) and aims to facilitate the prediction and validation of plant enzyme functions through three key activities. First, CSU will deposit published plant enzyme activities into public databases to support computational function...
This National Science Foundation Project Grant of $921,054 supports research to develop new biological functions through engineering plant hormone receptors. Led by the Regents of the University of California, Riverside under the Biological Sciences program (CFDA 47.074), the project engineers plant sensors to recognize pharmaceuticals and dietary molecules. It then uses these sensors to design "sentinel cells" that indicate molecule presence through color changes. Specifically, the...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $300,000 in funding to Western University of Health Sciences to conduct collaborative research on the variability and regulation of the plant polyadenylation complex. The research aims to better understand how this complex mediates gene expression and plant responses to environmental and developmental cues, with the goal of improving our knowledge of crop plant growth,...
This $794,457 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of new genetic analysis tools. The goal is to incorporate molecular and cellular biology knowledge, such as gene expression patterns and regulatory networks, directly into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype relationships. The research will be conducted using simulated...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports the development of an enhanced E3-DART protein degradation system for plant cell biology research. The primary awardee, Worcester Polytechnic Institute (WPI), will receive $259,157 over the award period from December 2024 to November 2026 to accomplish the following key objectives: Develop a ligand-inducible E3-DART system to enable chemically controlled protein degradation in...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences (CFDA 47.074) program provides funding of $993,190 to the University of Maine System to conduct research focused on engineering stable, transmissible plant minichromosomes for synthetic biology applications. The project, titled "NSF-DBT: PLANTSYNBIO: PLANT MINICHROMOSOME ENGINEERING", aims to develop methods that expand the limits of plant minichromosome size, structure, and composition to create a...
This National Science Foundation (NSF) Project Grant award under the Integrative Activities program (CFDA 47.083) provides $181,193 to the University of South Alabama to characterize the lipid and protein components of plant cell membrane nanodomains and their contributions to plant immunity. The project aims to explore how these membrane nanodomains change during plant responses to pathogen infections, using the model plant Arabidopsis thaliana and the crop potato. The research will employ...

This $234,063 National Science Foundation (NSF) project grant, awarded under the NSF Engineering program (CFDA 47.041), seeks to engineer plants to produce enhanced therapeutic proteins and improve protein production performance. The key objectives are to: 1) investigate the glycosylation and functions of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins (GPI-APs) engineered in plant cells; 2) assess the broader applicability and potential applications of GPI-APs in plant cells; and 3) engineer GPI-APs to improve existing plant cell lines for enhanced protein production. The project, led by Arkansas State University, will leverage the unique GPI anchor structure to promote intracellular trafficking, homogeneous glycosylation, and surface display of therapeutic proteins in plant cells. This may increase the bioavailability of orally administered biopharmaceuticals derived from plants. The project will also provide hands-on learning opportunities for graduate and undergraduate students and outreach to regional K-12 students to foster interest in science and technology. No subwards are planned for this award, which has a performance period from July 1, 2024 to June 30, 2027.

Generated 4/8/25, 4:04 AM