Mechanisms of lipid droplet protein targeting
Active Project Grant Awarded Last action
- Award ID
- R35GM158422
- Recipient
-
Sloan-Kettering Institute For Cancer Research UEI KUKXRCZ6NZC2
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $880,000
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 26% complete
- Place of performance
- New York, NY 10065, USA
Award details come from USAspending.gov.
Description
- Abstract
- LDS are essential organelles for lipid storage and metabolism. They are defined by a set of specific proteins on their surface, many of which accumulate and are implicated in etiology of common human pathologies, such as hepatic steatosis and cardiovascular disease. Recent advancements in understanding lipid droplet (LD) biology, mostly derived from studying drosophila cells, have illuminated key aspects of protein targeting to LDS. However, key challenges remain in determining how these pathways function in human cells, how physiologically important LD proteins (e.g., GPAT4 or atgl) target LDS and what the structural basis of LD protein targeting is. We have developed innovative methods to investigate LD targeting mechanisms, including single-molecule analysis and new assays for studying protein dynamics on LDS. We also will address the open question how proteins are removed from LDS under conditions of LD turnover. Findings from this work will address fundamental and yet unclear questions in cell biology. Since LD proteins are targets for therapeutic intervention for prevalent diseases, this work may also pave the way for devising novel therapeutic strategies against diseases linked to lipid dysregulation.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $440,000 | |
| Original award | $440,000 |
Quick answers
Who received award R35GM158422?
R35GM158422 was awarded to Sloan-Kettering Institute For Cancer Research by National Institute of General Medical Sciences (National Institutes of Health) on August 1, 2025.
How much is award R35GM158422 worth?
$880,000 has been obligated on R35GM158422.
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