The National Science Foundation awarded a $760,000 project grant to the Massachusetts Institute of Technology from February 1, 2021 through January 31, 2024. The grant is part of NSF's Biological Sciences program (CFDA 47.074) to promote advancement in the biological sciences. Under the award, MIT researchers will investigate protein regulators of three-dimensional genome architecture, dynamics, mechanism and function. Specifically, the grant will fund research into how proteins control the...
The National Science Foundation awarded a $367,636 Project Grant to the Massachusetts Institute of Technology from March 1, 2021 through February 29, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research on multidimensional single-cell phenotyping to elucidate relationships between genomes and phenotypes. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award supports...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
This federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program provides $1,041,774 to the Massachusetts Institute of Technology (MIT) for a collaborative research project focused on investigating the biological mechanisms that enable analog information storage in the chromatin state of cells. The primary objectives are to develop a model-driven, built-to-understand approach to dissect the molecular mechanisms governing analog versus binary...
The National Science Foundation (NSF) awarded a 5-year, $399,835 CAREER grant under the Biological Sciences program (CFDA 47.074) to the Massachusetts Institute of Technology (MIT) to investigate how transcription and loop extrusion regulate 3D genome structure. The project aims to improve the understanding of how a single genome gives rise to diverse cell types by studying the dynamics of CTCF-mediated DNA loops and topologically associating domains (TADs). The work will integrate advanced...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $263,800 to The Johns Hopkins University to investigate how supercoiled DNA impacts transcription, a core process that converts genetic information into RNA. The research will (1) characterize how supercoiling affects transcription kinetics and correlation in vitro, (2) examine how chromosomal topological domains impact gene expression in vivo, and (3) develop computational models...
This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
This Project Grant award of $136,600 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at William Marsh Rice University to develop advanced tools for directly visualizing, quantifying, and correlating DNA dynamics, organization, and gene activity in real-time. The project aims to overcome challenges in studying these essential processes for regulating gene expression and healthy cell function, which have been implicated in various diseases. The...
This Project Grant award of $300,000 from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) supports the development and experimental validation of computational tools for simulation-guided design of DNA nanostructures and molecular systems. The project aims to integrate high-level and low-level computational models to enable more powerful and user-friendly multiscale modeling frameworks for DNA nanotechnology. Key objectives include parameterizing coarse-grained...