This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), provides $357,033 to North Dakota State University (NDSU) from August 15, 2023 to July 31, 2026 to support research on protein manipulation and engineering using an electronic biochemical approach. The project aims to develop a single-molecule manipulation technique to study the dynamics of protein-protein interactions, which is critical for understanding the causes of diseases related to...
The National Science Foundation awarded a $599,940 Project Grant to the University of Chicago under the Mathematical and Physical Sciences program (CFDA 47.049) for research titled "COLLABORATIVE RESEARCH: DMREF: GOALI: HIGH-AFFINITY SUPRAMOLECULAR PEPTIDE MATERIALS FOR SELECTIVE CAPTURE AND RECOVERY OF PROTEINS." The four-year award beginning October 1, 2021 will support the development of new high-affinity supramolecular peptide materials for selective capture and recovery of...
The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to: Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions. Directly relate the observed domain unfolding of the...
This $360,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate biological mechanisms for proton transfer. The goal is to design photoacid-binding proteins that can spectroscopically study proton dynamics in biological systems. The research will leverage computational protein design tools to position photoacid cofactors within designer protein scaffolds to...
This $440,262 federal Project Grant award was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) grant program. The award supports a collaborative research project between professors at the Georgia Institute of Technology and Utah State University to study the evolution of archaeal protein tyrosine phosphatases (PTPs), a family of enzymes crucial for cellular signaling processes. The research aims to quantitatively...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate how chaperone proteins mediate proteasomal degradation of substrates. The principal investigator will use a multi-disciplinary approach, including in vitro characterization and cryo-electron microscopy, to study how the HSP70/CHIP/BAG-1 chaperone complex affects the various steps of proteasomal...
This $575,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will fund research at the University of California, San Diego to synthesize and study the reactivity of unusual main group elements stabilized by transition metal isocyanide complexes, from July 1, 2023 to June 30, 2026. Specifically, Professor Joshua S. Figueroa will manipulate boron monofluoride and diphosphorus molecules, which are...
This $525,000 Project Grant from the National Science Foundation Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will fund research at New York University from June 2022 to May 2025 to develop synthetic analogs of the small protein ubiquitin using block copolymers. Professor Marcus Weck will employ innovative design principles to fold and assemble artificial versions of ubiquitin through the use of folding synthetic polymers with protein-like...