Cornell University received a $1,177,301 Project Grant award from the National Science Foundation Division of Integrative Organismal Systems. The grant was awarded on July 1, 2023 under the Biological Sciences program (CFDA 47.074) to support research activities focused on developing computational tools and synthetic biology techniques to improve functional annotation of plant enzyme genes. Specifically, the grant will facilitate deposition of published plant enzyme activity data into public...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $726,093 to the University of Washington will fund research to develop programmable and tunable regulatory elements for predictable gene expression in plants. The goal is to enable the construction of multi-gene cassettes where each gene's expression can be controlled to optimize pathway flux. This will support the engineering of resilient, high-yielding crops and the production of...
The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) awarded a $464,968 project grant to the Boyce Thompson Institute for Plant Research Inc. This 3-year REU site grant, effective April 15, 2024, will support the training of 30 undergraduate students from underrepresented backgrounds in plant genome research at the Boyce Thompson Institute on the Cornell University campus. The students will develop interdisciplinary skills in data analysis, bioinformatics,...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $400,000 Project Grant under the Biological Sciences program (CFDA 47.074) to The Research Foundation for The State University of New York (SUNY) to study how natural product biosynthesis interconnects with the global metabolic network, using cardiac glycoside biosynthesis in the foxglove plant as an example. The project aims to elucidate the metabolic pathways underlying cardiac glycoside...
This $1,999,998 National Science Foundation Project Grant, funded under the Biological Sciences program (CFDA 47.074), supports research at the University of Washington to advance plant synthetic biology through deciphering the grammar of crop gene regulatory elements. The three-year award beginning March 1, 2023 will apply massively parallel reporter assays and machine learning to characterize tens of thousands of genetic regulatory elements in maize and tomato, including enhancers,...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) is providing $788,825 to The Trustees of Princeton University to advance the basic understanding of the principles underlying the assembly and architecture of pyrenoids - specialized cellular compartments found in certain algae and plants. The project aims to leverage this understanding to build a functional synthetic pyrenoid-based carbon dioxide-concentrating mechanism into the...
This $234,063 National Science Foundation (NSF) project grant, awarded under the NSF Engineering program (CFDA 47.041), seeks to engineer plants to produce enhanced therapeutic proteins and improve protein production performance. The key objectives are to: 1) investigate the glycosylation and functions of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins (GPI-APs) engineered in plant cells; 2) assess the broader applicability and potential applications of GPI-APs in plant cells; and 3)...
This National Science Foundation (NSF) Project Grant award, under the Biological Sciences program (CFDA 47.074), provides $240,000 over three years starting on September 1, 2024 to fund a Postdoctoral Research Fellowship in Biology. The research aims to investigate the effects of bioengineered organisms on community assembly and ecosystem functioning in a soil microbial community. The fellow will use genetic engineering to create microbial consortia and study the impacts on community and...
This $3,429,350 Project Grant award from the National Science Foundation's Office of International Science and Engineering (CFDA 47.079) supports the "International Research Center for Enhancing Plant Resilience". The center aims to discover and harness natural products from plants and microbes to enhance crop resilience against environmental stressors like drought and heat waves. The research involves genomics, AI, and synthetic biology to identify and validate metabolites that can...
This Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $1,038,598 to the University of Delaware to develop two synergistic synthetic biology systems for deciphering the roles and regulation of genetic and biochemical pathways in the protective plant cuticle. Over three years from August 2022 to July 2025, the University will engineer yeast cells and plant roots lacking a cuticle to systematically refactor the transcriptional regulatory...