This $3,429,350 federal Project Grant award, funded by the National Science Foundation's Office of International Science and Engineering program (CFDA 47.079), supports an International Research Center for Enhancing Plant Resilience. The center brings together experts from the U.S., Canada, Japan, South Korea, and the U.K. to explore sustainable solutions for global food production through the development of natural products and biotechnology. Key objectives include enhancing crop resilience to environmental stressors, reducing reliance on synthetic fertilizers and irrigation, and facilitating widespread adoption of sustainable agricultural practices. The research pipeline involves identifying and synthesizing beneficial plant and microbial metabolites, validating their bioactivity, and assessing their environmental impact. This multidisciplinary, international collaboration also focuses on public engagement, workforce development, and transitioning the center's innovations to industry and government partners. The award period runs from January 1, 2025 to December 31, 2029, with plans for subawards to support the collaborative research efforts.