This three-year National Science Foundation Project Grant of $626,850 supports research to develop a holistic understanding of plant cuticle assembly through synthetic biology approaches. Funded under the Biological Sciences program (CFDA 47.074), the grantee—the University of Nebraska—will engineer yeast and plant root systems lacking natural cuticles to model cuticle metabolism pathways. Researchers will refactor transcriptional networks and metabolic processes to produce synthetic cuticle...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $429,656.00 to Cornell University to conduct research using synthetic biology methods to engineer microorganisms to produce valuable plant natural products. The key objectives are to reconstitute plant biosynthetic machinery in yeast in order to better understand and harness plant enzyme complexes for natural product synthesis. This research aims to develop a more resilient...
This Project Grant award of $1,206,583 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support research at The Pennsylvania State University to investigate how plant cells regulate the delivery and recycling of cellulose synthase complexes to the cell membrane. The project aims to utilize quantitative live-cell imaging, proteomics, and functional genetics to enhance the understanding of cellulose biosynthesis and plant cell growth mechanisms....
This $794,457 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of new genetic analysis tools. The goal is to incorporate molecular and cellular biology knowledge, such as gene expression patterns and regulatory networks, directly into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype relationships. The research will be conducted using simulated...
This Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) provides $192,052 to the Board of Regents of the University of Nebraska to investigate the cellular and biomechanical mechanisms of rapid stomatal dynamics in grasses. The project will utilize molecular genetics, cell biology, computer vision, mechanical testing, and computational modeling techniques to gain a better understanding of how...
This Project Grant award, provided by the National Science Foundation's Biological Sciences (CFDA 47.074) program, aims to engineer predictable gene expression in plants to improve agricultural practices and ensure food security. The University of Washington is the primary awardee, receiving $726,093 over a 3-year period starting on April 1, 2025. The key objectives of this project are to: 1) develop a large repertoire of programmable and tunable synthetic regulatory elements, 2) precisely...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $300,000 in funding to Western University of Health Sciences to conduct collaborative research on the variability and regulation of the plant polyadenylation complex. The research aims to better understand how this complex mediates gene expression and plant responses to environmental and developmental cues, with the goal of improving our knowledge of crop plant growth,...
This $1,999,998 National Science Foundation Project Grant, funded under the Biological Sciences program (CFDA 47.074), supports research at the University of Washington to advance plant synthetic biology through deciphering the grammar of crop gene regulatory elements. The three-year award beginning March 1, 2023 will apply massively parallel reporter assays and machine learning to characterize tens of thousands of genetic regulatory elements in maize and tomato, including enhancers,...
This three-year $1.28 million project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Washington State University to develop a quantitative understanding of lipid metabolic network structure, fluxes, and sub-cellular spatial organization in plant seeds. The goal is to elucidate how plants balance oil accumulation with membrane lipid synthesis to optimize seed oil production without affecting membrane properties. The project will...
Cornell University received a $1,177,301 Project Grant award from the National Science Foundation Division of Integrative Organismal Systems. The grant was awarded on July 1, 2023 under the Biological Sciences program (CFDA 47.074) to support research activities focused on developing computational tools and synthetic biology techniques to improve functional annotation of plant enzyme genes. Specifically, the grant will facilitate deposition of published plant enzyme activity data into public...