This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $730,000 to the University of California, Los Angeles (UCLA) aims to transform the field of protein engineering through the development of an innovative technology called PicnnnShells. PicnnnShells are tiny, hollow particles that can rapidly screen up to one million different protein variations in a single day to identify useful proteins for research, industrial or medical applications. The project has two main objectives: 1) to develop methods for retaining antibodies and enzymes within PicnnnShells to expand their use beyond current fluorescent protein sensor applications, and 2) to create a comprehensive workflow for the directed evolution of proteins, specifically targeting high-performing variants of fluorescent calcium and glucose biosensors. The outcomes of this project will provide the research community with a transformative tool for accelerating protein design and development, leading to new discoveries in medicine, energy, and environmental science. No subawards are planned under this award, which has an ultimate completion date of July 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $730.0k | 7/22/24 |