This $394,704 National Science Foundation Integrative Activities Project Grant supports the design and characterization of biofilm-inspired amyloid biomaterials at The University of Southern Mississippi from August 1, 2022 to July 31, 2025. The grant aims to establish relationships between protein sequence, structure, processing, and material properties through a series of de novo peptides designed to mimic curli amyloid sequences. Researchers will synthesize peptides and characterize their...
This $1,500,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will support research at Northwestern University to develop innovative protein-based biomaterials. The research aims to (1) engineer mussel foot proteins with superior underwater adhesive properties compared to wild-type sequences, and (2) create resilin-inspired bioelastomers with high strength while retaining natural mechanical resilience. The proposed...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $730,000 to the University of California, Los Angeles (UCLA) aims to transform the field of protein engineering through the development of an innovative technology called PicnnnShells. PicnnnShells are tiny, hollow particles that can rapidly screen up to one million different protein variations in a single day to identify useful proteins for research, industrial or medical applications. The...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to: Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions. Directly relate the observed domain unfolding of the...
This $500,000 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key objectives are to: (i) synthesize and computationally simulate de novo designed proteins and their respective protein-polymer networks, and (ii) develop techniques for mechanical characterization...
Through a $249,997 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, researchers at the University of New Haven are developing a novel enzyme-responsive polyolefin material as a programmable antifouling coating. The research aims to understand how the properties of these polyolefin surfaces, such as hydrophobicity and texture, impact their ability to prevent and remove microbial adhesion from bacteria and algae commonly...
This $196,435 National Science Foundation Integrative Activities Project Grant supports research at the University of Southern Mississippi and collaborating institutions to elucidate heterogeneous single chain conformation and dynamics in thin polymer films through optical imaging. The University of Southern Mississippi Principal Investigator and a graduate student will work with experts at Rice University using single-particle tracking and single-molecule Förster resonance energy transfer...
This $525,000 Project Grant from the National Science Foundation Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will fund research at New York University from June 2022 to May 2025 to develop synthetic analogs of the small protein ubiquitin using block copolymers. Professor Marcus Weck will employ innovative design principles to fold and assemble artificial versions of ubiquitin through the use of folding synthetic polymers with protein-like...
The National Science Foundation (NSF) awarded a $612,259 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Georgia Tech Research Corp, a non-profit research organization, to conduct research on the synthesis and application of bioorthogonally degradable polymers. The research explores methods for the reversible assembly and functionalization of polymers through bioorthogonal reactions, with the goal of developing new biomaterials for potential applications...
This $574,915 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research by Professor Monika Raj of Emory University to develop new chemical probes and strategies for detecting and studying modifications to the amino acid histidine in proteins. The goal is to create novel chemical probes capable of selectively labeling modified histidine residues in proteins and capturing the...
This $157,688 National Science Foundation Integrative Activities award will support the development of bioactive surfaces through non-covalent protein-polymer conjugation strategies at the University of Southern Mississippi from June 2023 through May 2025. The goal of the project is to create regenerative protein-decorated surfaces with ease of removal and reapplication of active recombinant proteins for applications such as self-cleaning, antibacterial, and therapeutic surfaces. The Principal Investigator will employ histidine tag affinity ligand chemistries commonly used in recombinant protein purification coupled with reversible-addition fragmentation chain transfer polymerization to attach proteins to surfaces in a manner that avoids denaturation and maintains activity. Successful completion of this proof of concept approach will provide a platform for high-performing bioactive coatings with potential to address challenges associated with interacting with everyday surfaces and advance applications in health, agriculture, transportation, defense, and food processing. Mentorship will be provided by Professor Heather Maynard of the University of California, Los Angeles, an expert in protein-polymer conjugation.