Project Grant 2337393

Award Date 6/15/24
Completion Date 5/31/28
Dollars Obligated $150K
Funding Federal Agency
Office of Integrative Activities
Federal Grant Program
47.083
Assistance Type
Project Grant
Place of Performance
Los Alamos, NM 87544, USA
Similar Awards
This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
This federal Project Grant award of $899,982 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research effort to study X-chromosome inactivation and genome organization in human cells. The research team from New York University, Harvard University, and the New Mexico Consortium will integrate advanced genomics data, computational modeling, and biophysical approaches to unravel the complex folding of the X-chromosome and its impact on...
This four-year, $1.388 million project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between New York University and other organizations to discover the principles of active self-organization in the differentiating genome. The research will integrate state-of-the-art live cell experiments with multiscale mathematical and computational models of chromatin dynamics in the cell nucleus. Experiments will...
This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
This $899,100 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate developmental constraints shaping human sex chromosomes and escape from X chromosome inactivation. The research aims to: 1) demonstrate the impact of monosomy-X (loss of the second sex chromosome) on placental gene expression using human induced pluripotent stem cell models, and 2) elucidate...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
This $120,227 project grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program supports research at Northeastern University to develop a new theoretical approach for studying the three-dimensional architecture and conformational ensembles of genes and gene clusters. The project aims to: (i) model the mechanics of chromatin at the gene scale, (ii) investigate how genomic conformations are affected by factors like supercoiling and...
This $430,241 Project Grant award from the National Science Foundation's (NSF) Division of Physics, under the Mathematical and Physical Sciences program (CFDA 47.049), is funding research at Yale University to characterize the dynamics of intrachromosomal contacts within eukaryotic cells. The project aims to measure the "first passage times" - the duration it takes for distal locations on a chromosome to come into meaningful contact - through deployment of a specialized fluorescent...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) was provided to Brandeis University to conduct research investigating the role of heterochromatin and the protein HP1 in maintaining epigenetic memory and gene expression patterns in cells. Specifically, the $229,840 award will fund research to: (1) engineer synthetic H3K9me binding modules to test how DNA compartmentalization influences epigenetic memory, (2) determine how...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....

This $149,999 Project Grant award from the National Science Foundation's Integrative Activities (CFDA 47.083) program will support a collaborative research effort to model X-chromosome inactivation in human cells. The principal investigators from New York University, Harvard University, and the New Mexico Consortium will leverage expertise in molecular biology, genomics, computational biology, biophysics, and biomolecular modeling to investigate the complex genome organization and epigenetic regulation of the X-chromosome. The research aims to deepen the understanding of X-chromosome inactivation and its implications for related gene function and disease. The project will also provide interdisciplinary training for young scientists and enhance public outreach through a museum exhibit. No subawards are planned under this grant, which has an award date of June 15, 2024 and an ultimate completion date of May 31, 2028.

Generated 4/8/25, 4:41 AM