The National Science Foundation (NSF) awarded a $800,000 Project Grant under its Biological Sciences program (CFDA 47.074) to The Regents of the University of California, doing business as University of California, Berkeley. The grant funding will support collaborative research to discover and characterize compact CRISPR gene editing systems that can be encoded in plant viruses. This will enable more efficient and widespread deployment of genome editing capabilities across a variety of crop...
This $322,020 Project Grant award from the National Science Foundation's (NSF) Division of Integrative Organismal Systems will support collaborative research at the University of California, Davis (UC Davis) to develop improved methods for CRISPR/Cas9-based gene editing in maize. The key objectives are to generate maize lines expressing high levels of Cas9 nuclease and to engineer and optimize viral vectors to efficiently deliver guide RNAs for both somatic and heritable gene editing. This...
The University of California, Davis (UC Davis) has been awarded a $300,000 EAGER (Early-concept Grants for Exploratory Research) grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences. The grant supports a project to investigate the use of CRISPR gene editing technology to separate closely linked beneficial and harmful traits in plants. Specifically, the project aims to determine whether eliminating certain DNA repair pathways, such as the Ku-dependent...
The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a $277,978 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of California, Berkeley. The 3-year grant, beginning on Sep 1, 2023, aims to develop new tools and resources to enable more efficient gene editing in maize, the world's most produced crop. Specifically, the project will generate maize lines that constitutively express the Cas9 gene editing enzyme and engineer...
This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program totaling $100,000 will support research to develop next-generation clustered regularly interspaced short palindromic repeat (CRISPR) systems for curing inherited diseases. Specifically, the awardee, the University of California, Berkeley, will work to circumvent in vivo delivery challenges with CRISPR-Cas9 by developing miniature RNA-guided genome editors smaller than Cas9 that can be...
This National Science Foundation (NSF) Biological Sciences program grant awarded to New York University (NYU) is titled "EAGER: A GENOME WIDE HDR ENHANCEMENT SCREEN IN MAIZE." The $300,000 award, made on May 1, 2024, funds a 2-year project to develop an efficient method for using CRISPR gene editing technology to transfer stress-tolerant traits between plant varieties. The project aims to identify genes in maize (corn) that can enhance the efficiency of CRISPR-mediated...
The National Science Foundation awarded a $307,400 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Missouri System to develop epigenetic editing tools for improving crop plants. The project aims to expand the capabilities of genome editing by enabling targeted changes in gene expression, rather than just DNA sequence, to generate novel traits in important crops like rice and tomato. Key objectives include adapting the epigenetic editing approach...
The University of Maryland, College Park was awarded a $1,205,836 Project Grant from the National Science Foundation Division of Integrative Organismal Systems under the Biological Sciences federal grant program (CFDA 47.074) for the period of March 1, 2022 through February 28, 2025. The grant funds the development of highly efficient and unconstrained CRISPR systems for plant functional genomics. Specifically, the University will utilize the funding to advance CRISPR technology for analyzing...
This federal Project Grant award of $1,192,499.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research by the Donald Danforth Plant Science Center in Missouri to develop epigenetic editing tools for crop improvement. The key objectives of this 4-year project are to: 1) Expand epigenetic editing technologies to other crop species beyond cassava, such as rice and tomato, to enable disease resistance; 2) Demonstrate additional applications of...
This Project Grant award in the amount of $1,211,545.00 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop highly efficient and robust Prime Editing (PE) systems in rice, tomato, and poplar plants. PE is a cutting-edge CRISPR/Cas gene editing technology that enables precise replacement, addition, or removal of specific DNA sequences. The project objectives are to optimize PE proteins, improve PE guide RNA structure and expression, and modify...