This $616,151 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The research aims to improve the understanding of how tissues form, how embryos develop, and how diseases progress, with potential implications for advancements in tissue engineering and medicine. The 3-year project, set...
This National Science Foundation Project Grant of $492,743 will fund research into the impacts of intracellular and extracellular hydraulic environments on mammalian cell migration in confined spaces. Awarded on October 15, 2022 under the Engineering program (CFDA 47.041), the funding will support mathematical modeling to decipher the coupled effects of fluid interaction with cellular structures on cell behavior in confined migration. The awardee, the Research Foundation for the State University...
This $314,769 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (CFDA 47.083) program supports research to advance the fundamental understanding of mechanobiological signaling in cells and tissues. The University of Delaware, a private research university, will develop innovative magnetic material platforms that can dynamically control local tissue stiffness to mimic various biological events. Through controlled experiments, the project aims to uncover the...
This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
This National Science Foundation Project Grant of $419,750 will fund research at Washington University in St. Louis from August 1, 2022 to July 31, 2025 to study how living cells move across dissimilar physical environments and retain mechanical memories of prior environments. Specifically, the award will integrate experiments and computational modeling to examine how forces generated by cells modify their surroundings in two mechanically different environments during migration. This will reveal...
The National Science Foundation (NSF) awarded a $400,000 Project Grant under the Engineering program (CFDA 47.041) to the New Jersey Institute of Technology (NJIT) to advance the understanding of how new blood vessels grow in the body. This 3-year project aims to develop data-driven models that integrate high-fidelity biophysical simulation with high-resolution imaging of real blood vessel networks undergoing growth and adaptation. The research will elucidate the fluid dynamics and biophysics...
This National Science Foundation (NSF) Biological Sciences program Project Grant, with an award date of October 1, 2023 and total funding of $256,667.00, supports the development of advanced computational models to measure cellular traits in microscopy images. The goal is to create a universal deep-learning model that can readily quantify cell morphology in any microscopy image, with minimal training required. Specific objectives include developing methods for learning and extracting...
This Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 - Engineering) supports a $320,155 research project at Purdue University to investigate the complex flow and transport processes within microvascular networks and their impact on vascular remodeling. The key objectives are to develop a novel computational model integrated with high-resolution imaging data to gain fundamental understanding...
This Project Grant award of $401,889.00 was provided by the National Science Foundation (NSF) through its Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The grant aims to develop a novel mathematical model that integrates experimentally measured intracellular tensions to establish a force architecture throughout migrating cells. This will help identify the key subcellular components and pathways by which external properties direct cell migration, with applications in...
This Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program (CFDA 47.083) supports the development of a computational modeling framework that integrates machine learning with first-principles multiscale models. The $245,403 grant awarded to Kansas State University (KSU) will enable an assistant professor and graduate student to collaborate with the Terasaki Institute for Biomedical Innovation to create models that accurately predict disease...