Syracuse University has been awarded a $338,480 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) to develop a 3D computational model of epithelial stratification and turnover in skin tissue. The three-year award beginning May 1, 2023 will support the university's research using biophysical modeling and collaboration with cell biology experiments to quantitatively predict the mechanical response of self-renewing stratified epithelia. Specifically, the...
This Project Grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation provides $406,551 to Syracuse University under the Engineering (47.041) federal grant program. The funding supports research into probing cellular dynamic mechanobiology using human cardiomyocytes on a stimuli-responsive nano-topographic substrate from Nov 1, 2021 to Oct 31, 2024. Specifically, the awardee will develop new understanding of how human heart muscle cells respond to...
Syracuse University was awarded a $668,729 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation under the NSF Engineering program (CFDA 47.041). The award will support research into the biomechanics and mechanobiology of vimentin intermediate filaments and their role in cell motility and nuclear stability. Specifically, the university will investigate how vimentin enables cells to sense and respond to mechanical stresses, and study...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $411,125 to Syracuse University to develop a microfluidic human placenta model using human trophoblast stem cells derived from induced pluripotent stem cells. The key objectives are to generate microfluidic placenta organoids, examine the role of YAP signaling in regulating...
This Project Grant award, valued at $149,926 and provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports research to elucidate the physical principles governing how avian embryos control their dynamic geometry during the critical developmental stage of gastrulation. The Principal Investigator (PI) at the University of California, San Diego (UCSD) will develop mathematical models integrating cell-scale behaviors and...
This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Worcester Polytechnic Institute (WPI) in the amount of $259,570 will develop 3D spheroid models using patient-derived trophoblast cells to investigate placental cell invasion and study preeclampsia, a pregnancy complication with high global maternal and infant mortality rates. The 2-year project will design culture conditions to maintain the spheroid models, engineer an extracellular matrix to mimic the...
This $400,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to Cornell University aims to uncover the fundamental mechanistic principles of connective tissue morphogenesis and develop computational design tools to guide robotic micromanipulation for engineering architected biological tissues. The research will utilize computational models, imaging, and mechanical characterization techniques to study the influence of dynamic mechanical...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $253,033 to Appalachian State University to examine the role of tissue mechanics in brain folding during development. The research aims to advance the understanding of neural development, tissue engineering, and evolutionary brain changes by analyzing growth rates, tensile forces, and material properties of developing mouse cerebellum tissue that contribute to folding...
This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...