The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $1,068,821 Project Grant to the University of Pittsburgh for the project "Collaborative Research: Alpha-Arrestins' Impact on Cellular Physiology." This research, conducted under the NSF Biological Sciences program (CFDA 47.074), focuses on understanding how a class of proteins called alpha-arrestins regulate nutrient transporters to maintain metabolite balance and mitochondrial function in eukaryotic cells. The project aims to transform the understanding of alpha-arrestin function, define their impact on cellular metabolism and mitochondrial activity, and develop educational activities to engage undergraduate, graduate, and high school students in this research. Key activities include mapping metabolic changes in cells with impaired alpha-arrestins, defining the nutrient transporters regulated by alpha-arrestins, and using high-content microscopy to link alpha-arrestin-mediated transporter trafficking to mitochondrial form and function. The grant period runs from July 2023 to June 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.1m | 7/14/23 |