The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $1,068,821 Project Grant to the University of Pittsburgh for the project "Collaborative Research: Alpha-Arrestins' Impact on Cellular Physiology." This research, conducted under the NSF Biological Sciences program (CFDA 47.074), focuses on understanding how a class of proteins called alpha-arrestins regulate nutrient transporters to maintain metabolite balance and mitochondrial function in...
The University of Utah will receive $492,516 from the National Science Foundation Division of Molecular and Cellular Biosciences under a three-year Project Grant award titled "Role of Electric Fields and a Dynamic Local Environment in Protein-RNA Molecular Recognition." The grant funds basic research from August 1, 2021 to July 31, 2024 to advance understanding of major problems in the biological sciences by investigating the role of electric fields and the local molecular...
The University of Utah will receive $812,067 in funding from the National Science Foundation under the Biological Sciences federal grant program (CFDA 47.074) for the project "SAXOPHONE: A GLUCOSE-SENSITIVE TYPE I DPP/BMP RECEPTOR" from January 15, 2022 through December 31, 2024. The funding will support research exploring major problems confronting the nation through increasing scientific knowledge and enhancing understanding of the biological sciences. Specifically, the University of...
The National Science Foundation (NSF) has awarded a $1,099,440 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of California, Los Angeles (UCLA) to investigate the intracellular distribution and trafficking pathways of coenzyme Q (CoQ), an essential molecule for cellular respiration and antioxidant defense. The 3-year project, starting April 1, 2024, aims to characterize three key proteins that regulate the movement of CoQ within yeast cells, with the goal...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program provides $376,902 to the University of Pittsburgh for a research project titled "Mechanisms of Alpha-Arrestin-Mediated Protein Trafficking". The project will focus on investigating how alpha-arrestin proteins regulate protein trafficking in cells, which is critical for maintaining cellular homeostasis. The...
This $307,015 federal Project Grant awarded by the National Science Foundation's Biological Sciences program to the University of Utah aims to investigate the mechanisms regulating the lipid droplet proteome. The research will use multiscale simulations and collaborative experiments to understand how proteins selectively target and interact with lipid droplets in response to varying metabolic conditions. Findings from this work could provide insights to guide future therapeutic interventions for...
The National Science Foundation awarded a two-year Project Grant of $138,000 to Kent, Washington under the Biological Sciences federal grant program (CFDA 47.074) beginning November 1, 2021 through October 31, 2023. The grant funding will support research examining how adipokine control of the epigenome impacts an organism's starvation response. Specifically, the grant recipient will decipher how signaling molecules released by fat tissue regulate gene expression through epigenetic mechanisms...
The National Science Foundation (NSF) has awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Delaware. The objective of this 3-year grant, which runs from August 2024 to July 2027, is to develop a new strategy for real-time metabolite sensing and metabolon formation using biomolecular condensates. The research aims to create synthetic ligand-responsive transcription factor-based protein devices that can translate metabolite-induced DNA...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded Emory University a $724,356 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate the role of the protein ARL13B in controlling ciliary cyclic AMP (cAMP) signaling. The research aims to unravel the ciliary cAMP "signature", optogenetically stimulate cAMP signaling within normal and ARL13B-excluded cilia, investigate the role of ciliary cAMP signaling in remodeling...
The National Science Foundation (NSF) awarded a $432,000 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Utah. The funding supports a research project led by Professor Jon Rainier that aims to utilize light-driven photoelectrocyclization reactions to synthesize complex, optically active molecules with potential pharmaceutical, agricultural, and materials applications. The project seeks to uncover fundamental photochemical phenomena and...