The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $206,912 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of North Carolina at Chapel Hill. The three-year grant, effective August 1, 2023 through July 31, 2026, supports collaborative research to enhance the understanding of protein structures and behaviors at extreme temperature and pressure conditions. The research aims to develop rules for predicting protein...
This $795,135 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Illinois on protein dynamics under extreme environmental conditions. The four-year award beginning June 1, 2022 will fund three related subprojects investigating how proteins adapt to enable organism survival in stressful environments like heat, pressure and dehydration. The research will study intrinsically disordered protein structure and...
This $326,557 federal Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences Program (CFDA 47.049) will support research to develop and characterize novel biomaterials made from folded globular proteins. The key objectives are to: (1) experimentally characterize the mechanical response of protein building blocks under varying force, geometry, and solution conditions; (2) directly relate protein domain unfolding to the mechanical properties...
The National Science Foundation (NSF) awarded a $750,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of North Carolina at Chapel Hill (UNC-CH) to study the effects of macromolecular crowding on protein stability and interactions. The 3-year project will develop and test a new model for explaining how crowded cellular environments impact the free energy, enthalpy, and entropy of protein and protein complex stability. Key activities include using 19F NMR...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $785,201 Project Grant to The Regents of the University of Colorado to support research titled "Collaborative Research: Understanding Protein Mechanical Stability and Its Impact on Secretion." The two-year grant running from January 15, 2022 to December 31, 2024 will fund research under the Biological Sciences program (CFDA 47.074). The Biological Sciences program aims to promote progress in the...
This federal Project Grant award of $100,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports collaborative research to develop deep learning-based "consistency models" that can simulate the long-time dynamics of protein structures more efficiently than traditional molecular dynamics simulations. The research aims to overcome limitations in capturing millisecond-scale protein behavior, which is crucial for understanding processes like...
This $100,000 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports the development of deep learning-based computational models to simulate long-duration protein dynamics more efficiently than traditional molecular dynamics simulations. The research, conducted by the University of Missouri System, aims to create "consistency models" that can predict probabilistic distributions of molecular states with larger time steps,...
This $120,681 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports collaborative research by Syracuse University to investigate how intrinsically disordered proteins and cellular environments work together to protect organisms from desiccation as the climate changes. The project will employ a multi-level, interdisciplinary approach, spanning experiments on individual molecules, cellular-level studies in yeast, and...
The National Science Foundation awarded a $357,365 Project Grant to the University of Denver under the Biological Sciences federal grant program (CFDA 47.074) for work titled "COLLABORATIVE RESEARCH: CIBR: INCORPORATING CRYSTALLOGRAPHY AND CRYO-EM TOOLS IN FOLDIT." The three-year award running from June 2021 through May 2024 will support research incorporating crystallography and cryo-electron microscopy tools to advance protein structure prediction. The Biological Sciences program...
The National Science Foundation awarded a $298,911 Project Grant to New York University under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support collaborative research on water-responsive, shape-shifting supramolecular protein assemblies. Over a three-year period from August 2023 to July 2026, NYU will work with professors from New York University, CUNY Advanced Science Research Center, and CUNY City College to develop protein polymers that can respond to...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $710,128 Project Grant under the Biological Sciences (CFDA 47.074) program to The Research Foundation For The State University Of New York (SUNY) to conduct collaborative research on the "Energy Landscapes of Designed Cold Unfolding Proteins." The research aims to enhance understanding of the distinct three-dimensional shapes that proteins can adopt at extreme cold temperatures and high pressures, which is critical for advancing research on protein function, disease, vaccine development, drug formulation, and the engineering of "cold-adapted" proteins. The project employs a unique approach combining computational protein design, biophysical techniques, and molecular dynamics simulations to test hypotheses related to the structural and thermodynamic properties of cold-unfolding protein states. The award will support cross-interdisciplinary training, including the participation of underrepresented groups, and the development of new computational design protocols to facilitate the engineering of cold-unfolding proteins. This research aligns with NSF's mission to promote the progress of the biological sciences and strengthen the nation's scientific enterprise.