Project Grant 2317399
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and the Division of Chemical, Bioengineering, Environmental and Transport Systems awarded a $240,000 Project Grant to the University of California Irvine (UC Irvine) under the NSF Biological Sciences program (CFDA 47.074). The grant supports collaborative research to develop unnatural cofactors that can be deployed as stronger-than-nature thermodynamic driving forces in biomanufacturing processes. This is...
- The National Science Foundation (NSF) has awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Delaware. The objective of this 3-year grant, which runs from August 2024 to July 2027, is to develop a new strategy for real-time metabolite sensing and metabolon formation using biomolecular condensates. The research aims to create synthetic ligand-responsive transcription factor-based protein devices that can translate metabolite-induced DNA...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $414,164 Project Grant under the Biological Sciences CFDA program to the University of Illinois at Chicago. This 3-year grant, awarded on August 15, 2023, will support research to study how enzymes in intermediary metabolism interact with and bind to RNA molecules. The project aims to gain a greater understanding of these protein-RNA interactions and their effects on regulating cellular activities,...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $647,750 Project Grant to Princeton University under the Biological Sciences grant program (CFDA 47.074) to develop a closed-loop control system for regulating microbial communities. The project aims to integrate optogenetic controls and metabolite biosensing to dynamically modulate the composition and productivity of synthetic microbial communities for the production of valuable chemicals. The...
- This $400,546 Project Grant was awarded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program. The funding will support a collaborative research project between investigators at the University of California, Irvine (UCI) and partners in Switzerland to use a rapid gene evolution system called Orthogonal DNA Replication (OrthoRep) to prospectively evolve simple artificial metalloenzymes into advanced biological enzymes. The goal is to understand how enzymes...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- The University of California, Davis was awarded a $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The grant falls under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increasing knowledge and understanding of major problems. Specifically, the grant will fund research from August 1, 2021 to July 31, 2023 exploring an...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $500,000 in funding to The Regents of the University of Colorado to develop a suite of fluorescent RNA-based biosensors for monitoring metabolites in the methionine cycle of one-carbon metabolism in live cells. The project aims to create a "plug-and-play" toolkit of biosensors that can be used to study the dynamics and flux of central metabolites involved in regulating...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant to The Washington University in St. Louis to support research and training related to understanding how metabolic burdens affect microbial cells used in biotechnology applications. The 3-year award, which commenced on August 15, 2023, will enable the Principal Investigator to acquire expertise in modern metabolomics and gene editing techniques, and apply these methods to...
- This National Science Foundation (NSF) Project Grant award, under the Biological Sciences program (CFDA 47.074), provides $246,762 to the University of California Irvine (UC Irvine) from April 1, 2024 to March 31, 2026. The project aims to develop a deeper understanding of the principles governing how biological organisms build robust and precise traits from variable and unreliable components, and how these insights can be applied to improve the resilience of engineered systems. Key focus...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology bioprocesses. Key products and services include: The research approach spans core disciplines and aims to create tool sets that are transferrable to other eukaryotic systems like mammalian cells to address fundamental questions about metabolism regulation and rewiring.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $590.0k | 7/17/23 |