This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), provides $357,033 to North Dakota State University (NDSU) from August 15, 2023 to July 31, 2026 to support research on protein manipulation and engineering using an electronic biochemical approach. The project aims to develop a single-molecule manipulation technique to study the dynamics of protein-protein interactions, which is critical for understanding the causes of diseases related to...
This $298,345 Project Grant award from the National Science Foundation's Division of Materials Research (CFDA 47.049 - Mathematical and Physical Sciences) supports North Dakota State University's collaborative research to develop and study polymeric nanoparticles that can simultaneously enable targeted drug delivery and ultrasound imaging. The objective is to engineer nanoparticles that release their encapsulated therapeutic cargo only in specific disease-associated chemical environments,...
The National Science Foundation (NSF) awarded a $500,000 Project Grant under the Engineering program (CFDA 47.041) to the South Dakota School of Mines & Technology. The primary objective of this 2-year award is to develop a cell-free method for producing biodegradable polyhydroxyalkanoate (PHA) polymers from agricultural feedstocks. Key anticipated research activities include: 1) engineering a microbial strain to synthesize PHA precursors from corn stover, 2) using thermostable enzymes...
This $249,118 National Science Foundation Mathematical and Physical Sciences project grant funds the development of stimuli-responsive, biocompatible and biodegradable polymeric nanomaterials for biomedical applications at the University of North Dakota from July 15, 2022 to June 30, 2024. Professor Binglin Sui and students will create a series of degradable polymer chains containing bio-cleavable bonds. The polymers and polymer-based nanosystems are designed to covalently conjugate...
The National Science Foundation (NSF) Division of Chemistry awarded a $200,000 Project Grant to the University of North Dakota (UND) to develop graphene- and polymer-based fluorescent nanozymes for the sensitive detection of metabolic biomolecules like glucose. The award, funded through the Mathematical and Physical Sciences (CFDA 47.049) program, supports the collaborative work of Professors Julia Zhao and Diane Darland to create nanomaterial-based sensors characterized by high stability,...
The National Science Foundation awarded a $252,841 project grant to the University of North Dakota's Division of Research & Economic Development to acquire an atomic force microscope. The award period runs from September 1, 2021 through February 28, 2023 under the NSF's Engineering program (CFDA 47.041). The Engineering program seeks to improve quality of life and economic strength by fostering innovation and excellence in engineering research. This particular award will allow the University...
This National Science Foundation (NSF) Project Grant, part of the Mathematical and Physical Sciences program (CFDA 47.049), will provide $150,620 to the Colorado School of Mines from March 1, 2025 to February 28, 2030 to advance research on polymer-mediated delivery of genome-editing proteins. The project aims to develop innovative methods to efficiently test different polymer designs and quickly identify the optimal polymers for delivering CRISPR/Cas9 nucleases and base editors to various...
The National Science Foundation awarded North Carolina State University $525,836 under the Mathematical and Physical Sciences program (CFDA 47.049) for a three-year project grant completing July 2025. The university will research self-organizing nucleic acid supramolecular assemblies with stimuli-responsive properties. Specifically, the project aims to develop a toolkit for constructing responsive nanoparticle-based materials using rationally designed RNAs as modular building blocks. Researchers...
This National Science Foundation project grant award of $270,728 provides funding from August 1, 2022 through July 31, 2025 to support research exploring self-organization of functional nucleic acid supramolecular assemblies with stimuli responsive properties. Funded under the NSF Integrative Activities program (CFDA 47.083), the award supports the University of Nebraska at Omaha and its parent institution, the Board of Regents of the University of Nebraska, in developing a toolkit for...
This Project Grant from the National Science Foundation provides $514,253 to North Dakota State University from September 2021 through August 2024 to support an undergraduate research experience program in big data analytics and machine learning. The award is part of NSF's Engineering grant program (CFDA 47.041), which aims to improve engineering research and education. Through this funding, North Dakota State University will deliver research experiences and training to undergraduate students in...
This National Science Foundation Project Grant of $676,969 supports research at North Dakota State University from May 1, 2023 to April 30, 2028 under the Engineering program (CFDA 47.041). The grant aims to advance fundamental understanding of enzyme interactions with stimuli-responsive nanoparticles at the nanoscale. Specifically, the Principal Investigator will develop histone-mimetic polymerosomes capable of selectively recognizing target enzymes like histone deacetylase, and study how their structural and functional changes are mediated by epigenetic enzymes. Insights gained from this research could enable new biomolecular delivery platforms and synthetic nanomaterials that mimic cellular organelles. The award also supports curriculum development and increased research involvement of underrepresented undergraduate students in North Dakota to strengthen the STEM workforce.