North Carolina State University received a $232,136 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences to conduct collaborative research understanding and controlling force generation by a centrin-based contractile system. The research aims to elucidate the mechanism of myoneme contraction in the ciliate Spirostomum ambiguum, which represents the most powerful known biological force generation. The team will combine experiments and...
The University of Chicago received a $206,128 National Science Foundation project grant under the Biological Sciences federal grant program (CFDA 47.074) to conduct collaborative research from June 1, 2023 through May 31, 2027. The research aims to elucidate the mechanism of myoneme contraction in the ciliate Spirostomum ambiguum, a model system for understanding force generation. The university will determine the factors modulating assembly and force generation of myonemes, the contractile...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $139,341 project grant to the Regents of the University of California, San Francisco (UCSF) under the NSF Biological Sciences program (CFDA 47.074). The 3-year grant, effective August 1, 2023, supports collaborative research to investigate the biomechanical mechanisms underlying wound resilience in the single-celled organism Stentor coeruleus. The research will leverage cell biology, microfluidics, and...
The Regents of the University of California, San Francisco (UCSF) received a $284,636 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The two-year award will support research establishing novel tools to artificially manipulate chromosome folding and modulate various genome functions, including enhancer regulation of gene expression. Specifically, the grant will fund...
The Regents of the University of California, San Francisco (UCSF) received a $1,242,532 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on June 15, 2021 to fund research through May 31, 2025. The grant supports research to define how transcriptionally active euchromatin and repressive heterochromatin domains are maintained over multiple cell generations. Specifically, the University of California, San Francisco will investigate how the...
The National Science Foundation awarded a $1,715,342 project grant to The Regents of the University of California, San Francisco under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 through July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this osmotic model of...
The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
The Regents of the University of California at Riverside received a $1.56M Project Grant award from the National Science Foundation Division of Integrative Organismal Systems. The award is part of the NSF's Biological Sciences program (CFDA 47.074) and will fund research from September 2021 through August 2025 to decipher the robustness mechanisms of the stem promoting transcription factor gradient. The Biological Sciences program aims to advance the field and strengthen the national...
This $899,809 project grant from the National Science Foundation Division of Integrative Organismal Systems, under the Biological Sciences program (CFDA 47.074), will fund research to elucidate the molecular and cellular mechanisms governing ciliate-algal symbiosis. The grantee, Regents of the University of California at Riverside, will utilize a single-celled ciliate model to identify genotype-phenotype relationships and discover novel genes governing endosymbiosis with dinoflagellate algae....
The University of Cincinnati was awarded an $851,499 National Science Foundation Project Grant under the Biological Sciences federal grant program (CFDA 47.074) for research titled "NSF-BSF: SYNERGISTIC MULTISCALE MODELING AND SINGLE-MOLECULE FLUORESCENCE STUDIES OF THE DYNAMICS AND FUNCTION OF AAA+ PROTEIN DISAGGREGATION MACHINES." The research will involve multiscale modeling and single-molecule fluorescence studies to examine the dynamics and function of AAA+ protein...