The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) awarded a $550,000 Project Grant to The Trustees of Smith College for the research project "RUI: HEDGEHOG DEPENDENT CRANIAL NEURAL CREST CELLS PATTERN THE ZEBRAFISH FOREBRAIN." The grant will support a 3-year research effort to investigate the role of neural crest cells in the development of the vertebrate forebrain, using the zebrafish model system. The research will employ advanced microscopy techniques...
This $269,821 Project Grant awarded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support a research project at Hope College to study the regulation of the membrane transporter System xC- under oxidative stress conditions. The project aims to use advanced mass spectrometry techniques to identify post-translational modifications and signaling pathways that modulate the activity and localization of this critical antioxidant transporter. The grant will...
This $495,341 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Smith College to investigate the G protein-coupled receptor GPR37 and its role in regulating the maturation of new neurons in the adult hippocampus. The project aims to build on preliminary findings that suggest GPR37 may potentiate Wnt signaling to positively influence the integration of newborn neurons into established brain circuits. Key aspects of...
This $298,134 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research exploring the role of environmental nitrite and nitric oxide in modulating olfactory function in goldfish. Principal investigator Texas State University will study how goldfish uptake nitrogenous compounds in their noses, how nitric oxide is generated to control neuronal activity even under low-oxygen conditions, and whether nitric oxide can be produced through...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $549,900 to the Marine Biological Laboratory (MBL) in Woods Hole, MA will support the training of 30 undergraduate students over 3 summers from 2025-2027. The program will provide a rich research experience, with students fully immersed in their mentors' laboratories to learn how research is conducted. Students will engage in independent experiments focused on neurobiological and cellular processes...
This National Science Foundation (NSF) Project Grant under the Engineering Program (CFDA 47.041) awarded $600,000 to the University of Illinois at Chicago to develop a new method for manipulating neural circuit development by transferring and replicating neural signals from one brain to another using optogenetic technology in zebrafish larvae. The goal is to demonstrate the feasibility of replicating neural signals and mitigating malfunctioning circuits in zebrafish, which will lay the...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $400,000 to the President and Fellows of Harvard College from July 2024 to June 2027 will support research to understand the mechanisms that enable the acoel worm Hofstenia miamia to regenerate its entire head, including a new brain, and tail in the correct location. The key objectives are to investigate: 1) how cell signaling events activated by injury initiate asymmetric gene expression...
The National Science Foundation (NSF) awarded a $200,000 CAREER grant titled "REJUVENATION OF PLASTICITY IN THE MATURE BRAIN" to the Georgia Tech Research Corporation (GTRC) on September 1, 2024. The 5-year project will investigate how vision loss can reopen critical periods for neural plasticity in the visual and auditory cortices of mice. The primary research objectives are to evaluate how visual deprivation alters thalamocortical and experience-dependent plasticity, examine the...
The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award of $360,000 aims to uncover the intricate ways neurons communicate and how this communication influences brain development and maturation. The 5-year project, starting April 1, 2025, will utilize the model organism Caenorhabditis elegans to study the role of neuron-neuron communication, particularly through neurotransmitter-based and neuropeptidergic chemical neurotransmission, in the post-mitotic...