This $202,728 federal Project Grant awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program funds a collaborative research project to develop a theragnostic (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project aims to integrate data science, synthetic biology, and additive manufacturing to model the complex interplay of host, microbial, and environmental factors in IBD, and develop an engineered...
This $149,403 federal Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to North Carolina Agricultural and Technical State University (NC A&T) aims to develop a "theragnostic" (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project integrates data science, synthetic biology, and additive manufacturing to: 1) model the complex interactions between host, microbial, and environmental factors underlying...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000.00 to Eugit Therapeutics, Inc. to develop a novel platform for identifying agents that can specifically accumulate in diseased tissues. The primary goal is to create a proof of concept demonstrating the ability to uncover agents capable of targeted delivery to the gastrointestinal tract, with a focus on improving treatments for...
The National Science Foundation (NSF) awarded a $439,996 Project Grant to the Illinois Institute of Technology (IIT) through the NSF Engineering (ENG) program (CFDA 47.041) to develop microfluidic devices that can incorporate gut bacteria to generate and study intestinal organoids. The goal is to elucidate how gut microbes modulate the development and absorptive functions of intestinal cells, which is crucial for understanding drug effectiveness variability. In parallel, the project will provide...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $270,000 provides funding for a postdoctoral research fellowship to study the small intestinal microbiome. The key objectives are to elucidate how individual gut microbes and microbial communities respond to host factors like oxygen levels and bile acids, and how this impacts their ability to protect against pathogens. The research will leverage a novel capsule device to sample chemicals and viable...
This Project Grant award of $104,917 from the National Science Foundation's (CFDA 47.074) Biological Sciences program will support a team of undergraduate students at the University of Virginia in developing a low-cost treatment for exocrine pancreatic insufficiency. The students will design and build a probiotic that secretes synthetic pancreatic enzymes, with the goal of providing this treatment solution for the International Genetically Engineered Machines (iGEM) competition in synthetic...
This $353,843 Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) will support the development of programmable and dynamically-responsive bacterial therapeutics for cancer immunotherapy. The project aims to create a novel biosensing system in E. coli bacteria that can recognize extracellular cancer antigens and respond with therapeutic payloads. In parallel, the researchers will engineer bacteria with improved tumor colonization capabilities...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $548,949 Project Grant (CFDA 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of California, San Diego (UCSD) to develop a novel diagnostic technique for accurately profiling the gut microbiome. The project aims to create a "living biosensor" that can record extracellular DNA as it traverses the intestinal tract, preserving information about...
This Project Grant award, totaling $233,600.00 and spanning September 1, 2024 to June 30, 2027, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD), a debilitating condition characterized by chronic inflammation and erosion of intestinal functions. The...
This National Science Foundation (NSF) CAREER grant under the Biological Sciences (CFDA 47.074) program, awarded to the University of Rochester, seeks to develop a practical approach for controlling and stabilizing microbial communities. The 5-year, $376,301 project will leverage computational modeling and synthetic engineering to design a platform that uses plasmid conjugation to self-regulate microbial population growth and composition. This innovative approach aims to create programmable,...
This National Science Foundation (NSF) Project Grant, awarded under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070), provides $168,690 to the Florida Institute of Technology Inc. (Florida TECH) to develop a theragnostic (therapeutic + diagnostic) system for inflammatory bowel diseases (IBD).
The project aims to model the complex interplay of host, microbial, and environmental factors that trigger IBD using data science, and then leverage synthetic biology and additive manufacturing to create an engineered bacteria-based system that can detect and treat IBD. The research team will build an engineered bacterium that can sense IBD biomarkers and express anti-inflammatory compounds, and then develop a 3D-printed smart pill to safely deliver this theragnostic system to the gastrointestinal tract. This work has the potential to improve treatment and quality of life for millions of individuals with IBD worldwide. The project also includes an educational component to engage underrepresented students in STEM fields.