Project Grant 2306047
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $364,550 to Amherst College to study the rules for designing active DNA materials using condensing agents. The key objectives are to investigate how condensing agents can bend, loop, and reconfigure DNA in order to impart desirable properties like decreased size, increased stability, and altered electrical conductivity. The research will be conducted entirely by...
- The National Science Foundation (NSF) Division of Chemistry awarded a $460,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Drs. Harish Vashisth from the University of New Hampshire and Esteban A Orellana Vinueza from Dartmouth College. The 3-year grant, effective September 1, 2025, supports collaborative research to study how chemical modifications to transfer RNA (tRNA) bases affect the structure, folding, and dynamics of tRNA isodecoders, which are...
- This $510,000 Project Grant awarded by the National Science Foundation's (CFDA 47.049 Mathematical and Physical Sciences) program provides funding to Dr. Jia Sheng and Dr. Ting Wang at the University at Albany, State University of New York (SUNY) to develop novel photoswitchable nucleotide building blocks and incorporate them into RNA oligonucleotides to control their structures and functions. The research aims to create light-responsive RNA molecules that can serve as photoswitchable regulators...
- This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
- The National Science Foundation (NSF) awarded a $600,000 project grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Research Foundation of the City University of New York (RFCUNY) to support Professor Mahesh Lakshman's research on developing novel chemical methods for modifying nucleosides. Nucleosides are the fundamental building blocks of DNA and RNA, and this research aims to obtain a better understanding of chemical processes to enable selective modifications...
- This Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $630,000 in funding to the University of Texas at Austin to develop innovative mass spectrometry methods for characterizing nucleic acid structures. Professor Jennifer S. Brodbelt and her research group will design and implement new analytical techniques that integrate high-performance mass spectrometry and ion mobility separations to elucidate the structures...
- The National Science Foundation (NSF) Division of Chemistry awarded a $1,500,000 Project Grant to Stanford University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The grant, awarded on March 1, 2024, supports a 3-year research project titled "Evaluating and Advancing Cryo-EM for RNA Conformational Ensembles." The project aims to: (1) design, model, and experimentally probe RNA systems with discrete conformational states, and (2) characterize and challenge...
- This Project Grant award from the Division of Chemistry at the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $600,000 to support Professors Jennifer Schomaker and Jeffrey Martell at the University of Wisconsin-Madison, along with Dr. Jing Chai at GSK, in advancing DNA-encoded chemical library (DECL) technology. The key objectives are to develop mild oxidative reactions that preserve the integrity of DNA tags, broadening the scope of drug...
- The National Science Foundation awarded a $430,000 Project Grant to The Washington University in University City, Missouri under the Mathematical and Physical Sciences program (CFDA 47.049) from October 1, 2025 to September 30, 2028. The grant supports research to develop "bilingual biopolymers" - synthetic molecules that can simultaneously encode both nucleic acid and protein information. The project aims to modify the protein code of these biopolymers to control their assembly,...
- This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program, provides $551,717 in funding to the University of Washington for a 3-year project period from August 1, 2024 to July 31, 2027. The project, led by Professor Frantisek Turecek, focuses on developing new chemical reactions for crosslinking biomolecular ions representing components of proteins and nucleic acids. The research...
The National Science Foundation Division of Chemistry awarded Professor Jennifer Heemstra of Washington University in St. Louis a $444,812 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new methods for temporally controlling nucleic acid function through reversible "caging." Over the two-year period from December 2022 to September 2025, the grantee will explore using glyoxal and related compounds to selectively cage and stimuli-responsively decage nucleic acids, enabling temporal control of their structure and function. Specific objectives include developing chemical lithography for selective caging of long RNA segments, exploring modified bis-aldehyde reagents for nucleic base cloaking of DNA and XNAs, and utilizing glyoxal caging to study the role of snRNA structure and protein binding in Cajal body formation and RNA trafficking. The research aims to provide tools advancing biotechnology and further fundamental understanding of nucleic acid properties and biological functions such as biomolecular condensates implicated in neurodegenerative diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.8k | 12/14/22 |