Project Grant 2532420
- This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
- The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
- The National Science Foundation (NSF) awarded a $480,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Arizona State University (ASU) for the development of a general method to assemble large, ordered 3D protein biomaterials using non-canonical amino acids. The primary goal is to create "coordinated protein frameworks" - extended protein lattices with defined geometries and tunable distances between the assembled proteins. This approach promises to...
- The National Science Foundation (NSF) awarded a $420,553 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to The Washington University in St. Louis. This collaborative research project aims to develop novel polymer materials with unprecedented mechanical properties and self-healing capabilities through an integrated experimental and computational approach. The key products and services to be delivered include: Pioneering the use of double-threaded slide-ring...
- This $1,120,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) aims to explore the boundaries of life's genetic alphabet beyond the natural 4-letter system (A, T, G, C). The research will develop model systems to study the biomolecular properties of a 6-letter genetic alphabet (A, T, G, C, P, Z) and map critical interactions necessary for translation of this expanded genetic code. The project will use synthetic biology and chemical...
- This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
- This Project Grant award from the National Science Foundation (CFDA 47.049 - Mathematical and Physical Sciences) provides $140,390.00 to the University of Illinois to conduct research on the design of protein-like materials from pi-conjugated peptides. The research aims to develop porous peptide frameworks by appending peptides with flat aromatic molecules prone to stacking, which could guide the predictable self-assembly of these materials. The goal is to uncover the rules that allow chemists...
- This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials. The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of...
- The National Science Foundation Division of Chemistry awarded Professor Jennifer Heemstra of Washington University in St. Louis a $444,812 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new methods for temporally controlling nucleic acid function through reversible "caging." Over the two-year period from December 2022 to September 2025, the grantee will explore using glyoxal and related compounds to selectively cage and...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), in the amount of $642,000, will fund research at Northwestern University to develop novel hybrid protein-DNA supramolecular structures. The key objectives are to: (1) design generalizable strategies for site-specific DNA functionalization to control proteins in 1D arrays; (2) create dynamic, DNA-driven 2D protein lattices; and (3) utilize DNA interactions to facilitate...
The National Science Foundation (NSF) awarded a $430,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to The Washington University in St. Louis to support a 3-year research project titled "Harnessing the Peptide Code of Bilingual Biopolymers to Control Assembly and RNA Localization." The research will explore a novel class of "bilingual biopolymers" that can simultaneously encode both nucleic acid and protein information, providing greater control over molecular structure and function. Specifically, the project will investigate methods to modify the protein code to spatiotemporally regulate the chemical properties of these biopolymers, enabling enhanced control over their assembly and other activities. This will advance applications in areas such as drug delivery and sensing. The research will also leverage the dual nucleic acid and protein coding to modulate RNA localization within cells, with potential therapeutic implications. The project will provide an interdisciplinary training experience for undergraduate and graduate students while also contributing to public science communication.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.0k | 8/18/25 |