Project Grant 2246828

The National Science Foundation awarded a $575,000 Project Grant to the University of Colorado Boulder under the Mathematical and Physical Sciences program (CFDA 47.049) from July 1, 2023 to June 30, 2026. The grant funds fundamental research on the development of new stereoselective synthesis methods for challenging carbohydrate and glycomimetic systems of biomedical significance. Principal Investigator Maciej Walczak and his team will focus on cross-coupling reactions using stereodefined anomeric nucleophiles to install glycosidic bonds with high selectivity and control chirality across a range of substrates. They aim to bridge knowledge gaps in catalytic carbohydrate functionalization and stereospecific cross-coupling through exploration of underutilized C1 boronic acids and silanes. Specific targets include medically relevant C-glycosides, rare hexoses, and L-hexoses/L-aminosugars. Outcomes seek to facilitate complex carbohydrate synthesis and provide insights supporting fields like glycobiology and medicinal chemistry. Broader societal impacts include training the next generation of scientific leaders and engaging the public through STEM education outreach events.