This five-year, $397,457 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) supports research into engineering autonomic control of cardiac tissues. The principal investigator will develop heterotypic multicellular models to measure the effects of autonomic innervation on cardiac contractile behavior and cellular composition. Stem cells will be differentiated into sympathetic and parasympathetic neurons and mixed with cardiomyocytes at different developmental stages. A variable frequency electrical stimulation bioreactor will also be developed to mimic neuronal signals, allowing comparison of contractile properties between innervated, non-innervated, and electrically stimulated cardiac tissues. As part of the award, the investigator will integrate research and education through stem cell biology, biomanufacturing, and cardiovascular physiology activities for high school and undergraduate students in local rural school districts.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $397.5k | 1/9/23 |