This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is supporting a collaborative research effort focused on developing an intelligent lab-on-chip device to monitor and promote the maturation of stem cell-derived cardiomyocytes. The $192,150 award to the New York Institute of Technology (NYIT) aims to create an integrated system that can non-invasively evaluate cardiomyocyte maturity in real-time and adaptively apply electrical and mechanical...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $467,202 project grant to the Research Foundation of the City University of New York (RFCUNY) to develop an intelligent lab-on-chip device that can non-invasively monitor the maturation of stem cell-derived cardiomyocytes in real-time and apply adaptive biophysical stimulation to promote full cell maturation. The interdisciplinary research team from RFCUNY, City College of New York, and Rutgers University plans...
This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of...
This five-year, $397,457 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) supports research into engineering autonomic control of cardiac tissues. The principal investigator will develop heterotypic multicellular models to measure the effects of autonomic innervation on cardiac contractile behavior and cellular composition. Stem cells will be differentiated into sympathetic and parasympathetic neurons and mixed with cardiomyocytes at different...
This $100,000 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems supports the development of a 3D human stem cell cardiac model for cardiac electrophysiology medical device safety assessment. Funded under the NSF Engineering program (CFDA 47.041), this award will allow the University of Maryland, College Park to create a novel in vitro model for evaluating the safety and efficacy of cardiac medical devices through January...
This $262,138 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at the University of Houston to investigate the mechanisms of cardiac fibrosis, a type of scarring in the heart that leads to impaired function. The key objectives are to: 1) determine the role of the endothelial-mesenchymal transition in cardiac fibrosis, and 2) develop a 3D cardiac fibrosis model to study tissue remodeling. The research will leverage a...
This four-year Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems provides $480,000 to support research titled "COLLABORATIVE RESEARCH: RECODE: DIRECTING AND CONTROLLING CARDIAC DIFFERENTIATION THROUGH CELLULAR AND MICROENVIRONMENTAL MANIPULATION AND APPLICATION OF MACHINE-LEARNING." The research is being conducted under the NSF Engineering program (CFDA 47.041) to advance engineering innovation and...
The National Science Foundation (NSF) has awarded a $455,718 Faculty Early Career Development (CAREER) Project Grant to Marquette University to develop a living, tissue-engineered heart valve substitute capable of growing with child recipients of congenital heart valve defects. The 5-year project, funded under the NSF Engineering program (CFDA 47.041), aims to create a durable, hydrodynamically functional heart valve using an origami-inspired design and patient-derived cells that can self-repair...
This National Science Foundation (NSF) Engineering (CFDA 47.041) program grant, in the amount of $400,000, supports the development of a tissue-like, converged sensing platform for tracking excitation-contraction dynamics in cardiac organoids. The project aims to: Develop a scalable assembly strategy to fabricate an array of three-dimensional sensor structures using planar semiconducting graphene material, designed to detect both electrical and mechanical stimuli. Evaluate the multifunctional...
The National Science Foundation awarded a $279,606 Project Grant to the University of California Irvine under the Engineering federal grant program (CFDA 47.041). The grant supports collaborative research to develop multiscale computational models characterizing how heart muscle cells adapt mechanically to changes in load conditions. Through experimental measurement and multi-scale modeling, the university researchers will elucidate the acute functional response and long-term remodeling response...