This Project Grant award of $305,000.00 from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to revolutionize drug discovery by accelerating molecular dynamics simulations through advanced AI techniques. The project, awarded to Giwotech Inc. in Dorchester, MA, seeks to develop a robust neural network model capable of simulating protein systems up to 500 times faster than current GPU-based classical molecular dynamic simulators while...
This $274,797 National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award to Deepseq.ai LLC supports the development of an AI-driven platform to accelerate the identification of highly developable single-domain antibodies for drug discovery. The proposed work aims to create a multimodal AI model capable of rapidly screening large libraries to generate lead molecules with favorable binding affinity, stability, and manufacturability. This project...
This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $303,864 to Core Biotherapeutics Inc. to develop a platform for discovering therapeutic drugs that can reprogram molecular networks to treat diseases. The project aims to determine the biological laws driving diseases at the molecular network level and create an algorithm to rapidly identify drug targets. The key goals are to demonstrate that oligonucleotide drug...
This $1,000,000 Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to accelerate R&D in the pharmaceutical industry through the development of streamlined machine learning algorithms for small data applications in advanced manufacturing. The project, awarded to Sunthetics Inc., seeks to save time and resources by up to 95% in lead optimization and route scouting during pre-clinical drug development by...
This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $274,932 to Femtofluidics Incorporated to develop hardware that can rapidly and inexpensively synthesize DNA-encoded libraries (DELs) for accelerating drug discovery. The goal is to build a device that can perform combinatorial chemistry on nanoliter to picoliter volume droplets using an electronic substrate, without any moving or mechanical parts. This technology...
This Project Grant award of $275,000 from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a high-throughput platform for small molecule, in-cell targeting of undruggable proteins via their messenger RNAs (mRNAs). The award aims to create an efficient and cost-effective approach for developing therapeutics for previously undruggable diseases, including hard-to-treat neurodegenerative diseases and highly...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Delaqua Pharmaceuticals, Inc. aims to enhance the therapeutic use of hydrophobic drugs through a polymeric micelle approach to drug solubilization. The key objectives are to 1) improve the formulation of spherical micelles for enhanced stability and drug solubilization, 2) perform initial toxicity studies to establish the safety of the platform, and 3) demonstrate...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Technology Transfer (STTR) project grant, awarded to Vivosphere LLC, is developing a novel 3D tissue-engineered platform for cancer modeling and high-throughput drug screening. The $275,000 project aims to create a more physiologically relevant and scalable system to improve the translation of preclinical cancer drug candidates to clinical trials. Key objectives include testing...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Cerflux Inc. aims to develop a personalized cancer treatment screening platform. The project will establish guidelines for handling solid tumor biopsy samples, generate 3D bioprinted tumor models for validation, and demonstrate the platform's ability to match patients with the most effective cancer treatments before treatment begins. This innovative approach has the...
This Project Grant award of $305,000.00 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports Plexymer, Inc., a for-profit small business, to develop an artificial intelligence-driven platform for accelerated formulation of antibody therapeutics. The project aims to use AI and robotics to streamline the bioformulation process, potentially reducing the time and materials required to prepare antibody drugs for subcutaneous...