Project Grant 2230470

Award Date 1/15/22
Completion Date 7/31/23
Dollars Obligated $805K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Grand Rapids, MI 49503, USA
Similar Awards
This National Science Foundation project grant of $502,553 will fund research at the University of North Dakota from April 2023 through March 2026 under the Biological Sciences federal grant program (CFDA 47.074). The research will study molecular mechanisms regulating the poly(ADP-ribosyl)ation pathway in living cells, using the fruit fly Drosophila as a model system. Specifically, the project will characterize molecular targeting and regulation of two key enzymes, PARP1 and PARG, that...
This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins involved in gene regulation. The key objectives are to investigate how chemical modifications, such as phosphorylation and methylation, of RNA polymerase II and associated regulatory proteins trigger the release from promoter-proximal pausing and...
This Project Grant award from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) provides $949,958 in funding to Rutgers, The State University of New Jersey, Camden Division to conduct research on the role of inorganic polyphosphate (polyP) in regulating mitochondrial physiology in mammals. The project aims to elucidate the molecular mechanisms by which polyP influences mitochondrial bioenergetics in normal and...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $300,000 in funding to Western University of Health Sciences to conduct collaborative research on the variability and regulation of the plant polyadenylation complex. The research aims to better understand how this complex mediates gene expression and plant responses to environmental and developmental cues, with the goal of improving our knowledge of crop plant growth,...
The National Science Foundation awarded a $1,109,203 Project Grant to The Research Foundation For The State University Of New York to elucidate the role of protein arginine methylation in regulating RNA-binding protein function from May 2021 through April 2025. This award supports research under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing scientific knowledge and...
This $360,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The project aims to develop new peptide nucleic acid (PNA) molecules capable of selectively recognizing and binding to double-stranded non-coding RNA. This research addresses an important challenge in RNA biochemistry and could enable...
This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
This $820,000 Project Grant was awarded on July 15, 2023 by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The grant supports a collaborative research effort involving four research labs, two in the U.S. and two in Israel, to investigate RNA editing enzymes called ADARs (Adenosine Deaminases Acting on RNA). The goal is to advance the understanding of how ADAR enzymes can be used by different organisms to...
This $1,079,254 National Science Foundation project grant supports research investigating mechanisms of RNA polymerase II transcription and regulation using single molecule fluorescence techniques at the University of Colorado Boulder from March 2023 through February 2027. The research will study the assembly and disassembly of key protein complexes involved in early transcription stages using microscopy to observe individual molecules. Specifically, the research will investigate how the human...
This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...

This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $804,836 to the Van Andel Research Institute to study the role of poly(ADP-ribose) polymerase 1 (PARP1) in regulating RNA polymerase II elongation and mRNA splicing. The award aims to advance understanding of PARP1's function in RNA biogenesis through large-scale genomics and gene-specific approaches to map PARP1's genetic and biochemical interactions with RNA and chromatin. It also seeks to elucidate the mechanisms by which PARP1 modulates chromatin structure to regulate alternative splicing and RNA processing. A $80,483 subaward to the University of Kentucky Research Foundation will support analysis of PARP1's DNA and RNA binding properties to further define its mechanisms of interaction. The award period is January 15, 2022 through July 31, 2023 and reflects the NSF's mission to promote biological sciences research strengthening the nation's scientific enterprise.

Generated 1/7/24, 1:38 AM