Project Grant 2231403
- This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $804,836 to the Van Andel Research Institute to study the role of poly(ADP-ribose) polymerase 1 (PARP1) in regulating RNA polymerase II elongation and mRNA splicing. The award aims to advance understanding of PARP1's function in RNA biogenesis through large-scale genomics and gene-specific approaches to map PARP1's genetic and...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 provides funding for a postdoctoral research fellowship from July 1, 2024 to June 30, 2027. The fellowship will support research and training to investigate the rules governing interactions between genomes, environment, and phenotypes, with a focus on understanding how repetitive DNA sequences, particularly a satellite repeat on the X chromosome of Drosophila melanogaster, influence...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program awarded a $722,198 Project Grant to the College of the Holy Cross to investigate how lineage-specific "orphan" genes contribute to the maturation and function of sperm in male Drosophila melanogaster (fruit flies). The research objectives include evaluating the extent to which these genes' functions are conserved across divergent fly species. The project will also expand the research capacity of the...
- This National Science Foundation Project Grant award of $1,324,710 provides funding from July 1, 2022 through June 30, 2025 to support research understanding how newly evolved genes acquire protein interactions and regulatory mechanisms in Drosophila reproduction. Funded under the Biological Sciences program (CFDA 47.074), the award to the College of the Holy Cross will explore how three genes essential for Drosophila melanogaster spermatogenesis evolved novel capabilities, including physical...
- This $660,000 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at the University of Southern California (USC) on how RNA editing regulates synaptic plasticity and behavioral adaptations in the fruit fly Drosophila melanogaster. The project aims to investigate how RNA editing of glutamate-gated chloride and voltage-gated calcium channels impacts neural circuit function, synaptic plasticity, and organismal behaviors....
- This $238,681 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) funds research into the genetic architecture of exploration behavior in Drosophila at the University of Houston-Downtown. The researchers will use novel arena exploration assays and integrated genetic approaches to identify genes and neurons responsible for neophilia, or attraction to novel stimuli. Specifically, they will determine dopamine signaling requirements for exploratory...
- This Project Grant award of $550,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Iowa State University to investigate how different histone writer enzymes coordinate to regulate gene expression and chromatin structure. The project will explore how the histone modifications H3K9me2, H3S10ph, and H4K16ac work together to fine-tune gene expression levels by controlling chromatin accessibility. Experiments will utilize Drosophila larval...
- This Project Grant from the National Science Foundation Division of Emerging Frontiers, under the Biological Sciences federal grant program (CFDA 47.074), provides $502,161 to Appalachian State University to investigate the impacts of evolutionary novelty on generalist species. Specifically, the award will fund research examining toxin tolerance in Drosophila tripunctata fruit flies that use diverse mushrooms and fruits as hosts. The university will test hypotheses about how toxin tolerance...
- This National Science Foundation (NSF) Project Grant, funded under the Biological Sciences program (CFDA 47.074), supports collaborative research at North Dakota State University (NDSU) to mechanistically examine aging dynamics across insect life stages and tissues. The $614,175 award from August 1, 2023 to July 31, 2026 will investigate how insect metamorphosis and overwintering dormancy (diapause) influence cellular senescence and organismal lifespan. The research aims to provide new...
- This $240,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) funds a postdoctoral research fellowship to investigate the role of genome organization on de novo gene origination. The research aims to test a new theoretical model explaining the process of new gene evolution, by examining how the genome's structural features influence the birth of genes that arise from non-coding regions. The key components of the research include: 1)...
This National Science Foundation project grant of $502,553 will fund research at the University of North Dakota from April 2023 through March 2026 under the Biological Sciences federal grant program (CFDA 47.074). The research will study molecular mechanisms regulating the poly(ADP-ribosyl)ation pathway in living cells, using the fruit fly Drosophila as a model system. Specifically, the project will characterize molecular targeting and regulation of two key enzymes, PARP1 and PARG, that control chromatin state and gene transcription through poly(ADP-ribosyl)ation. Experiments will probe mechanisms recruiting these enzymes to genomic loci and triggering poly(ADP-ribosyl)ation-dependent processes. Outcomes aim to advance understanding of this pathway's role in developmental gene regulation and how it may be modulated. Broader impacts include providing local students research opportunities to learn fundamentals of developmental biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $502.6k | 3/23/23 |