This $999,996 Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports fundamental research aimed at generating "designer mitochondria" for biotechnology, healthcare, and basic research applications. The key objectives are to identify the factors required for human mitochondrial DNA (mtDNA) replication and characterize the mechanisms underlying the species-specificity of this process. This work represents a critical step...
This $638,454 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Dartmouth College to define the functions of an essential, conserved mitochondrial protein that links the organelle's matrix to the cytoplasm. Over three years, the researchers will investigate how specific mitochondrial components integrate mitochondrial function within plant cells, focusing on the roles of ATAD3 proteins that span the inner and outer...
The National Science Foundation awarded a $138,000 Project Grant to support research from June 2021 to May 2023 titled "Uncovering the Molecular Mechanisms of Mitochondrial Proteostasis." The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing knowledge and enhancing understanding of major problems. Funds will support the grantee's research...
This five-year National Science Foundation project grant of $800,000 will fund research into mitochondrial transcellular communication in the nervous system and provide training opportunities for undergraduate students. The principal investigator at the University of Arizona will investigate the triggers, cellular machinery, and uptake mechanisms that regulate the transfer of mitochondria between glial cells and neurons in vivo using Drosophila genetics, microscopy, and imaging flow cytometry...
The National Science Foundation (NSF) has awarded a $236,098 CAREER grant under the Biological Sciences program (CFDA 47.074) to the University of California, Berkeley. The project, titled "CAREER: Mitochondrial Genome Partitioning and Quality Control," aims to investigate the mechanisms of mitochondrial genome inheritance and how it relates to mitochondrial function. The research will reveal how mitochondrial DNA transmission is linked to mitochondrial dynamics, identify molecular...
This $900,052 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into the molecular mechanisms governing cytoskeleton-mediated motility and distribution of peroxisomes and mitochondria in plants. The grant supports three years of collaborative research between Michigan State University and its sub-awardee to advance understanding of how these organelles recruit cytoskeletal motor proteins for directional transport along...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award provides $150,000.00 to the University of South Alabama to enhance mitochondrial DNA repair mechanisms. The project aims to re-engineer key DNA repair enzymes to improve their targeting and activity within mitochondria, which are critical cellular structures for energy production. This research addresses a critical gap in understanding mitochondrial base excision repair, a pathway essential for...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $280,000 over 3 years to Auburn University to investigate the roles of mitochondrial behavior and morphology in animal performance. The key objectives are to test the hypotheses that: 1) changes in mitochondrial shape and movement increase ATP production, and 2) mitochondrial characteristics play critical roles in how animals respond to factors like food availability,...
The University of California, San Diego will receive $2,844,000 under a three-year Project Grant from the Department of Health and Human Services' National Institute of General Medical Sciences to develop tools and models to decode mitochondrial morphology dynamics and predict cell fate decisions. The grant funds research from September 2022 to August 2025 under the Biomedical Research and Research Training program (CFDA 93.859). Specifically, the University will expand its prototype...
This $899,894 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program, CFDA 47.083, will support research to characterize the structure, membrane topology, substrate specificity, and biochemical properties of a unique mitochondrial HAD phosphatase enzyme in a divergent unicellular organism. The project aims to elucidate the dual functional roles of this enzyme, which may provide insights into the broader cellular functions of the related TIM50 protein...
This $1,000,000 four-year Project Grant from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund research at Northeastern University exploring the role of mitochondria in regulating cell fate decisions during early mammalian development. Specifically, the researchers will test the hypothesis that differential allocation of mitochondrial subtypes, which vary in biochemical properties and protein content including levels of the transcription factor TEAD4, drives specification of embryonic versus placental cell lineages in mouse preimplantation embryos. By analyzing mitochondrial heterogeneity and inter-organellar communication, the project aims to assess whether mitochondria function as "shuttles" guiding transcription factor distribution and thus cell fate determination through an undiscovered mechanism. The award will also support innovative training for undergraduate and graduate students from diverse backgrounds in state-of-the-art techniques to advance basic understanding of developmental biology and cell fate regulation.