Project Grant 2225568
- This $300,000 project grant from the National Science Foundation will fund research at Cornell University from October 1, 2022 to September 30, 2025. The award is provided through NSF's Engineering Biology and Health Cluster within the Directorate for Engineering, Biological Sciences and Biotechnology, under the CFDA program for Engineering. Specifically, researchers at Cornell University and Washington State University will work to develop new tissue engineering strategies for cartilage repair....
- This three-year, $1.2 million project grant from the National Science Foundation's Engineering program (CFDA 47.041) will support research at Washington State University and Cornell University to develop new tissue engineering strategies for cartilage regeneration. The researchers aim to stimulate adult stem cells to become mature chondrocytes for cartilage production through small molecules that interfere with bone cell differentiation genes. Real-time imaging will monitor cell growth...
- This $1,000,000 National Science Foundation project grant supports research at the University of Wisconsin-Madison to develop single cell-level programming of human induced pluripotent stem cell differentiation into chamber-specific cardiomyocytes. The goal is to generate cardiomyocytes from each chamber of the heart through precise control of Wnt and retinoic acid signaling at the single cell level via engineered genetic programs and superstructures. If successful, this approach could establish...
- The University of Colorado Denver received a $744,733 Project Grant award from the National Science Foundation on December 1, 2021 to support research titled "COLLABORATIVE RESEARCH: RECODE: ORGANOID MODEL OF GROWTH PLATE DEVELOPMENT." The grant will fund research through November 30, 2025 under the NSF Engineering Program (CFDA 47.041). The research aims to develop organoid models of growth plate development to better understand the molecular and cellular mechanisms that regulate...
- This four-year Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems provides $480,000 to support research titled "COLLABORATIVE RESEARCH: RECODE: DIRECTING AND CONTROLLING CARDIAC DIFFERENTIATION THROUGH CELLULAR AND MICROENVIRONMENTAL MANIPULATION AND APPLICATION OF MACHINE-LEARNING." The research is being conducted under the NSF Engineering program (CFDA 47.041) to advance engineering innovation and...
- This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of...
- This $400,000 Project Grant, awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), is funding a collaborative research project at the University of Michigan to study the mechanics of tissue boundary formation. The research aims to explain how mechanical forces inside the body help shape developing tissues during early stages of life, by investigating how cells move, interact, and respond to mechanical cues during tissue formation. The 3-year project will combine...
- This $500,000 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the University of Notre Dame's research exploring the differentiation of stem cells into patterned blood vessel networks using hybrid memristor technology. Over a four-year period from October 2022 to September 2026, the University will engineer the first autonomous hybrid memory resistor and cell culture device to control human pluripotent stem cell differentiation into...
- The National Science Foundation (NSF) has awarded a 5-year, $182,664 CAREER grant (CFDA 47.041 - Engineering program) to the Marshall University Research Corporation (MURC) to explore the use of electrospinning and electrospraying techniques for differentiating human adipose-derived stem cells into chondrocytes. The overarching goal is to develop an innovative and personalized approach to generate chondrocytes, or cartilage cells, that can be used for regenerative medicine applications focused...
- This $500,000 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation supports research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD" being conducted at Cornell University from January 1, 2022 to December 31, 2024. The research aims to improve understanding of instabilities and local strains in engineered cartilage scaffolds, with the goal of enabling innovation in cartilage...
This $1,000,000 National Science Foundation project grant will fund the Reproducible Cells and Organoids via Directed-Differentiation Encoding (RECODE) project at the University of Michigan from November 1, 2022 to October 31, 2026. The project aims to employ innovative biophysical, data-driven, and synthetic gene circuit engineering methods to better understand how adult human mesenchymal stem cells transform into chondrocytes, the cells that form cartilage. Specifically, the researchers will monitor how biophysical conditions drive the maturation of stem cell-derived chondrocytes into either stable articular cartilage chondrocytes or hypertrophic chondrocytes. Through high-throughput monitoring, RNA sequencing, and other omics techniques, the project will generate new knowledge and computational models of the transcriptional and translational regulators controlling chondrocyte differentiation. A synthetic gene circuit platform will then be used to engineer circuits that maintain desired chondrocyte phenotypes, with the goal of improving stem cell-based cartilage regeneration strategies. This work falls under the National Science Foundation's Engineering Directorate and its program supporting engineering research and education.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/10/22 |