Project Grant 2218467
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded $1,299,732 to the University of Texas at Austin under a Project Grant to support research titled "COLLABORATIVE RESEARCH: SYNTHETIC AND SYSTEMS BIOLOGY APPROACHES TO SEMI-SYNTHETIC CELLS WITH EXPANDED DNA ALPHABETS." The three-year award beginning August 15, 2021 falls under the Biological Sciences program (CFDA 47.074) to promote progress in the biological sciences and strengthen the Nation's...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program provides $1,332,516.00 to the University of Texas at Austin to develop synthetic cells that mimic the essential functions of biological platelets. The project aims to create light-activated, programmable synthetic cells that can undergo shape transformation, release biochemicals, and adhere to surfaces in a coordinated manner to promote blood clotting. This work addresses...
- This National Science Foundation (NSF) federal Project Grant award under the Biological Sciences program (CFDA 47.074) is funding the University of Illinois to construct a new type of self-replicating synthetic cell system. The $448,355 award from June 1, 2024 to May 31, 2027 supports the development of engineered synthetic cells that can grow, divide, and replicate their genetic information using nucleic acids as both structural and genetic components. The project aims to investigate the...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $1,028,700 to the University of Texas at Austin to investigate a previously unknown mechanism by which proteins on cell surfaces transmit information across membrane boundaries. The project aims to elucidate the fundamental biophysical mechanisms behind this "transbilayer coupling" of protein condensates, which could lead to new ways of controlling cellular behavior for...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Rice University a $373,174 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to conduct research toward developing lifelike synthetic cells through engineered control of DNA replication from August 15, 2021 to July 31, 2024. The Biological Sciences program aims to advance biological knowledge and understanding of major problems to strengthen the nation's scientific enterprise....
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and Division of Mathematical Sciences awarded a $550,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Texas at Austin. The grant, titled "COLLABORATIVE RESEARCH: MODULUS: PROTEIN DROPLETS DRIVE MEMBRANE BENDING AND CYTOSKELETAL ORGANIZATION," seeks to improve understanding of how protein droplets interact with cellular membranes and the cytoskeleton. The...
- This National Science Foundation Project Grant award of $937,018 provides funding for collaborative nanoscience research between the University of Texas at El Paso and Baylor College of Medicine. The award is made under the NSF Engineering Directorate's 47.041 CFDA program to support innovation and excellence in engineering research. Specifically, the researchers will investigate the influence of physical and chemical factors of nanomaterials on cell adhesion, protein synthesis, and cellular...
- The National Science Foundation (NSF) awarded a $297,984 Project Grant under the Engineering program (CFDA 47.041) to the University of Texas Health Science Center at Houston (UTHealth). The grant supports collaborative research to quantify the mechanical forces inside living cells and determine how changes in these forces impact the production and secretion of proteins that shape the cellular environment. The goal is to develop predictive tools using mechanical forces to control cell...
- This $1,230,301 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a multidisciplinary collaboration to explore the mechanical properties and genetic/biochemical basis of a potent adhesive biopolymer produced by bacteria. The research aims to provide a detailed mechanistic understanding of how these types of materials impart strong adhesion, with applications in developing biocompatible and water-tolerant adhesives. The award,...
This $3 million National Science Foundation project grant supports research at the University of Texas at Austin to develop synthetic adhesive cells for controlled intracellular delivery. Funded under the Biological Sciences program (CFDA 47.074), the three-year award will engineer synthetic cells with user-defined control over molecular transfer between synthetic and live cells. Researchers will build on prior work developing synthetic cells that form adhesive junctions and transfer cargo into live cells via gap junctions. By combining these capabilities and leveraging the natural ability of adhesive junctions to regulate gap junction assembly, the project aims to provide precise, engineered control over intercellular delivery. This will enable synthetic cells to safely reach their potential for applications in biotechnology, chemical sensing, production, and biomedicine. As the parent organization, the University of Texas System will also support delivery of the research products and services under this NSF grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 6/9/22 |