This $1.8 million project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Cornell University to develop single molecule tools and techniques for studying coronavirus membrane fusion. The goal is to understand the relationship between coronavirus fusion peptide sequence and target host cell membranes at the nanoscale. Specifically, the awardee will identify and measure the physicochemical interactions between the coronavirus spike...
The National Science Foundation Division of Environmental Biology awarded The Pennsylvania State University a $714,745 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) on July 15, 2022. The grant will fund research from July 2022 through June 2025 to identify the ecological role of spillover outcome on the evolution of disease emergence. The researcher will characterize virus dynamics and pathogen evolution following exposure of Caenorhabditis nematode hosts to...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $206,912 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of North Carolina at Chapel Hill. The three-year grant, effective August 1, 2023 through July 31, 2026, supports collaborative research to enhance the understanding of protein structures and behaviors at extreme temperature and pressure conditions. The research aims to develop rules for predicting protein...
The National Science Foundation awarded a $357,365 Project Grant to the University of Denver under the Biological Sciences federal grant program (CFDA 47.074) for work titled "COLLABORATIVE RESEARCH: CIBR: INCORPORATING CRYSTALLOGRAPHY AND CRYO-EM TOOLS IN FOLDIT." The three-year award running from June 2021 through May 2024 will support research incorporating crystallography and cryo-electron microscopy tools to advance protein structure prediction. The Biological Sciences program...
This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $387,783 to The Pennsylvania State University (Penn State) for a 5-year research project focused on understanding the dynamics of how pathogenic human viruses, such as enveloped RNA viruses (e.g., Dengue, Zika), non-enveloped RNA viruses (e.g., Coxsackie viruses), and non-enveloped DNA viruses (e.g., Human...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $785,201 Project Grant to The Regents of the University of Colorado to support research titled "Collaborative Research: Understanding Protein Mechanical Stability and Its Impact on Secretion." The two-year grant running from January 15, 2022 to December 31, 2024 will fund research under the Biological Sciences program (CFDA 47.074). The Biological Sciences program aims to promote progress in the...
This $100,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program supports the development of deep learning-based "consistency models" to simulate the long-time-scale dynamics of protein structures. The project aims to overcome the limitations of traditional molecular dynamics (MD) simulations, which are constrained by small time steps and unable to capture crucial long-duration protein behaviors like folding and...
The Trustees of the University of Pennsylvania were awarded a $185,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Mathematical and Physical Sciences program (CFDA 47.049). The grant will fund the development of testing and estimation methods for multi-modality single cell genomics from August 1, 2021 to July 31, 2024. The University of Pennsylvania will leverage the funding to advance scientific understanding of major problems in...
This Project Grant awarded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program provides $270,000 in funding from July 1, 2025 to June 30, 2028 to support a postdoctoral research fellowship focused on investigating the evolutionary determinants of protein biophysics. The research aims to characterize the relationship between protein thermodynamic stability and effective population size, examining how this balance between mutation, selection, and genetic...