The National Science Foundation (NSF) awarded a $184,017 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Missouri System, doing business as Missouri University of Science & Technology (Missouri S&T). The grant supports a collaborative research project led by Professors Pablo Sobrado and John Tanner studying the mechanisms, functional diversity, and conformational dynamics of flavin-dependent monooxygenase enzymes found in plants. The project aims to establish structure-function relationships for these enzymes using biochemical and structural approaches, including advanced kinetic methods and high-resolution X-ray crystallography. The research seeks to generate new insights into how evolution leverages flavin cofactors to catalyze diverse chemical reactions, with potential applications in the rational design of new catalysts and engineering of biochemical pathways to produce high-value compounds. The project also serves as a platform for training graduate, undergraduate, and high school students in relevant scientific disciplines.
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