Project Grant 2105998
- East Carolina University received a $140,677 Project Grant award from the National Science Foundation Division of Chemistry on June 1, 2021 to support research titled "Mechanistic and Structural Approaches for Sulfur Acquisition in the Two-Component FMN-Dependent Monooxygenases" through January 31, 2022. The award was made under the Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific fields and strengthen the national...
- Federal Grant Award Summary The National Science Foundation's Division of Chemistry awarded East Carolina University $525,000 under the Mathematical and Physical Sciences program (CFDA 47.049) for a three-year project grant running from September 1, 2025, through August 31, 2028. Professor Holly Ellis and her research team will conduct fundamental research to elucidate the functional and structural properties of a mercaptopropionate dioxygenase (MDO) and sulfurtransferase (ST) enzyme system...
- This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
- The National Science Foundation (NSF) awarded a $599,999 project grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Santa Barbara (UCSB) and the University of Pittsburgh. The 3-year collaborative project aims to investigate the detailed mechanisms and origins of selectivity in recently developed enzymatic reactions with unnatural electron transfer pathways. The research team, led by Professors Yang and Liu, will integrate computational tools...
- The National Science Foundation (NSF) awarded a $543,183 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Research Foundation for the State University of New York (RF SUNY), which serves as the fiscal agent for SUNY campuses. The grant, awarded on October 1, 2023, supports a study led by Andrew Murkin at the University at Buffalo on the mechanisms and inhibition of organic and enzymatic isomerization reactions. The key products and services to be...
- This Project Grant award, valued at $450,000.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program. The award, effective from August 1, 2024 to July 31, 2027, supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University. The objective of this research program is to elucidate the fundamental mechanisms by which a...
- This $391,121 National Science Foundation project grant supports collaborative research between Marquette University and the Colorado School of Mines under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year award will fund mechanistic studies of iron-type nitrile hydration catalysts through a combination of experimental and computational approaches. Researchers will employ kinetic, spectroscopic, biochemical, computational, and X-ray crystallographic methods to detect...
- Federal Grant Award Summary North Carolina State University received a $645,000 Project Grant from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) effective September 1, 2025 through August 31, 2028. Under the direction of Professor Makris, the research program investigates the structures and catalytic mechanisms of heme oxygenase-like dimetal oxidases/oxygenases (HDOs), a newly discovered class of bacterial enzymes...
- This $208,879 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between Marquette University and the Colorado School of Mines to gain molecular-level insights into the catalytic mechanism of nitrile hydratase enzymes. Professors Bennett, Fiedler, and Holz will employ kinetic, spectroscopic, biochemical, computational, and X-ray crystallographic methods to detect intermediates, test competing mechanistic...
- This $537,800 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports Professor Jochen Autschbach of the University at Buffalo, State University of New York, in developing and applying quantum theoretical methods and computer simulations to investigate the three-dimensional arrangement of atoms, chemical bonding, and molecular dynamics, and their impact on nuclear magnetic resonance (NMR) parameters and natural optical...
This three-year, $525,000 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports coordinated mechanistic approaches to desulfonation in two-component FMN monooxygenases. East Carolina University will deliver structural investigations of alkane sulfonate monooxygenase systems through X-ray crystallography and analysis, with the University of Massachusetts Boston performing the crystallography work. Quantum mechanical calculations of potential energy surfaces for reaction intermediates will also be conducted, with the University of Miami delivering these computations and associated data, structures, and reports to East Carolina University. The grant aims to advance understanding of major problems in the mathematical and physical sciences by promoting progress in these fields through this research on flavin-dependent monooxygenase enzyme reaction mechanisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $525.0k | 8/12/21 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
AWD210858S002S | University Of Mass At Boston | Project Grant 2105998 | $68.6k | 2/11/22 | |
AWD210858S001S | University Of Miami | Project Grant 2105998 | $58.1k | 1/19/22 |