Louisiana State University received a $524,334 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on December 15, 2021 to fund research exploring the mechanisms of nucleolar stress in Drosophila through November 30, 2024. The grant supports basic research aligned with the Biological Sciences program (CFDA 47.074) to advance understanding of major biological problems and strengthen the national scientific enterprise. Specifically, the funding...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program grant, awarded to the University of Texas at Arlington (UTA), aims to uncover the mechanistic details of how the overlapping networks of RNA interference (RNAi) and chromatin modifying pathways maintain appropriate gene regulation during stress. The $171,061 award, effective from February 15, 2025 to January 31, 2030, will leverage interdisciplinary approaches, including genetics, physiological assays,...
This $185,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports fundamental research on the spatial-temporal orchestration of the START transition in budding yeast cells. The research aims to elucidate the molecular mechanisms that control the timing and synchrony of the G1/S transition, which is critical for regulating cell size and fitness. The work will employ experimental and modeling approaches to investigate...
This $229,840 National Science Foundation (NSF) Project Grant awarded to Brandeis University on March 15, 2025 supports research under the NSF Biological Sciences program (CFDA 47.074) to investigate how a protein called HP1 helps cells maintain epigenetic memory. The research will use fission yeast as a model organism to: Engineer synthetic H3K9me binding modules to directly test how compartmentalization influences epigenetic memory, Determine how compartmentalization buffers cells from...
The National Science Foundation (NSF) awarded a $955,876 Project Grant to Northwestern University to investigate the role of prion-mediated epigenetic regulation in the budding yeast, Saccharomyces cerevisiae. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to examine how two different yeast prions, [SWI+] and [MOT3+], interact and impact global transcription and protein homeostasis. Using advanced multi-omics techniques, the research program will identify...
This Project Grant award, valued at $179,978, was provided by the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) to South Dakota State University (SDSU). The award will support research to understand how cells interpret and respond to stress through the stress kinase JNK and transcription factor c-Jun. Specifically, the project will examine two mechanisms: 1) post-transcriptional regulation of genes through mRNA stability, and 2) combinatorial regulation of...
This $276,308 National Science Foundation (NSF) grant under the Integrative Activities program (CFDA 47.083) supports the University of Oklahoma in developing novel computational and statistical methods for analyzing spatially-resolved single cell genomics data. The key objectives are to: (a) identify spatial gene expression patterns, (b) uncover changes and interactions within tissue during development or disease, and (c) create an interactive analysis tool for researchers. This 5-year...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
This National Science Foundation Project Grant award of $250,000 supports research at Louisiana State University from May 1, 2022 to April 30, 2025 under the Integrative Activities program. The research aims to define signaling pathways that control cytoskeletal networks during epithelial tube formation using the developing salivary glands of Drosophila melanogaster. Specifically, the project will identify and characterize unidentified salivary gland G protein-coupled receptors that reorganize...
This Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports research to quantify mechanical forces within living cells and determine their impact on cellular protein production and the surrounding environment. The $160,000 award to Boise State University aims to develop predictive mechanobiotechnology approaches to control cell behavior through externally applied mechanical forces. The research will create a digital representation...