Project Grant 2153432
- This National Science Foundation project grant of $1,011,518 supports collaborative research between the University of California, San Diego and the State of California Controller's Office to discover the principles of active self-organization in the differentiating genome. The award period is from July 1, 2022 through June 30, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The project will integrate state-of-the-art live cell experiments with multiscale mathematical...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
- This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
- This federal Project Grant award of $899,982 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research effort to study X-chromosome inactivation and genome organization in human cells. The research team from New York University, Harvard University, and the New Mexico Consortium will integrate advanced genomics data, computational modeling, and biophysical approaches to unravel the complex folding of the X-chromosome and its impact on...
- The National Science Foundation awarded a $501,269 Project Grant to Stanford University under the Mathematical and Physical Sciences program (CFDA 47.049). The grant will fund theoretical and computational modeling of supercoiling, topology, and active fluctuations in chromosomal organization and dynamics from September 2021 through August 2024. As part of the Mathematical and Physical Sciences program's goal of strengthening the Nation's scientific enterprise through increased understanding...
- This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- The National Science Foundation awarded New York University a $120,000 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop a mathematical model of mitosis. The award period is from June 15, 2022 to May 31, 2026. Under the award, NYU will build on previous work modeling cell division to create a more realistic simulation of closed mitosis. Researchers will extend their model to include a deformable elastic nuclear envelope integrating the...
- This $149,999 Project Grant award from the National Science Foundation's Integrative Activities (CFDA 47.083) program will support a collaborative research effort to model X-chromosome inactivation in human cells. The principal investigators from New York University, Harvard University, and the New Mexico Consortium will leverage expertise in molecular biology, genomics, computational biology, biophysics, and biomolecular modeling to investigate the complex genome organization and epigenetic...
- This $240,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) funds a postdoctoral research fellowship to investigate the role of genome organization on de novo gene origination. The research aims to test a new theoretical model explaining the process of new gene evolution, by examining how the genome's structural features influence the birth of genes that arise from non-coding regions. The key components of the research include: 1)...
This four-year, $1.388 million project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between New York University and other organizations to discover the principles of active self-organization in the differentiating genome. The research will integrate state-of-the-art live cell experiments with multiscale mathematical and computational models of chromatin dynamics in the cell nucleus. Experiments will characterize changes in genomic organization during cell differentiation before and after the process. This data will guide development of a novel coarse-grained computational model and first-principles continuum theories capable of capturing the wide range of time and length scales involved. The goal is to elucidate the fundamental physical principles governing reorganization of the differentiating genome. The award is expected to provide new educational opportunities for graduate and undergraduate students through training in advanced techniques and interdisciplinary skills in cell biology, polymer dynamics, fluid mechanics, and modeling.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $694.2k | 6/23/22 |