This $228,806 Project Grant from the National Science Foundation Division of Mathematical Sciences, under the Mathematical and Physical Sciences program (CFDA 47.049), will support collaborative research between the University of Houston and Baylor College of Medicine to develop comprehensive mathematical models of respiratory muscles, with a focus on the diaphragm. The research aims to improve understanding of diaphragm mechanics and generate analytical tools to quantify diaphragm...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $249,894 to the New York Institute of Technology (NYIT) to establish a comprehensive computational framework for hierarchical modeling of skeletal muscles. The project aims to advance the fundamental understanding of skeletal muscle biomechanics by integrating knowledge from computational methods, constitutive mathematical models, microstructural intricacies,...
This National Science Foundation (NSF) Project Grant award under CFDA 47.041 "Engineering" provides $373,596 to the University of Texas at Austin to delineate and model the intra- and extra-cellular mechanisms contributing to right ventricular (RV) myocardial stiffening. The research will use a combination of experimental and computational approaches, including micro-scale mechanical tests on individual cardiomyocytes and combined cardiomyocyte-extracellular matrix strip assemblies, as...
This $279,376 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) funds collaborative research at The Washington University to delineate and model the intra- and extra-cellular mechanisms contributing to right ventricular (RV) myocardial stiffening. The researchers will conduct micro-scale mechanical tests on individual cardiomyocytes and combined cardiomyocyte-extracellular matrix assemblies, including samples from healthy and diseased sheep with...
The National Science Foundation awarded a $409,795 Project Grant to the University of Houston System under the Engineering federal grant program (CFDA 47.041) to support fundamental research on the mechanics of active biological membranes from May 1, 2023 to April 30, 2026. The research aims to establish a rigorous theoretical framework integrating continuum mechanics and non-equilibrium statistical mechanics to model active membranes. Specifically, the university will focus on entropic...
This $195,101 Project Grant, awarded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074), will use mathematical modeling to project the healthcare burden associated with COVID-19, influenza, and respiratory syncytial virus (RSV) in the United States during the 2023-2024 respiratory virus season. The research will integrate estimates of population immunity from prior infections, vaccinations, and monoclonal antibody therapy to produce four rounds of projections...
Trustees of Boston University received a $566,473 National Science Foundation Project Grant under the Engineering (47.041) federal grant program. The five-year award funds research utilizing a novel transparent ribcage platform termed LUNGEX to probe multiscale mechanobiology of pulmonary respiration-circulation coupling in real-time. The platform will allow unprecedented visualization of lung microphysiology dynamics at the cellular level across nearly the entire lung surface. Specific aims...
The National Science Foundation awarded a $602,650 project grant to Northeastern University for research titled "ELUCIDATING THE ROLE OF COLLECTIVE CELL-MATRIX INTERACTIONS IN THE MECHANOBIOLOGY OF AIRWAY NARROWING." The five-year grant runs from July 1, 2021 through June 30, 2026 under the NSF Engineering Program (CFDA 47.041). The grant will fund research at Northeastern University in Boston, MA to improve understanding of how collective cell-matrix interactions influence airway...
This National Science Foundation project grant of $214,373 awarded to Arizona State University on April 1, 2022 through the Engineering (47.041) federal grant program will fund collaborative research examining the fluid dynamics of respiratory virus transport through lung liquid lining. Specifically, the award will support experiments and numerical modeling to capture the essential fluid interactions between lung surfactants and a model virus, simulating physiologically relevant scales....
This National Science Foundation Project Grant of $200,000.00, awarded on November 15, 2022 with a completion date of October 31, 2026, will fund research at Columbia University to develop behavior-driven mathematical models and forecasting systems for respiratory disease transmission in urban settings. Funded jointly by NSF's Division of Mathematical Sciences and Division of Social and Economic Sciences under the Biological Sciences program (CFDA 47.074), this research aims to incorporate...