This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) provides $279,226 in funding from August 1, 2024 to July 31, 2027 to the University of Houston System for a collaborative research project titled "Mechanics of the Topologically Complex Nuclear Envelope." The project aims to develop new fundamental insights into the mechanical properties of the nuclear envelope, which is essential for the survival and function of eukaryotic cells. The...
This $374,132 federal Project Grant award was provided by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) to the University of Houston System. The award will fund research aimed at unveiling the dynamics of liquid-like macromolecular condensed phases, from nucleation to stability. The project uses advanced computer modeling to explore the fundamental steps governing how macromolecules in solutions group together, with the goal of unlocking new possibilities...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant award of $342,318 supports research at the University of Wisconsin - Madison to develop a novel theoretical and computational framework for modeling the mechanical deformation and interactions of biomembranes with transport and electrochemical processes. The 3-year research project, starting on Sep 1, 2024, aims to create an open-source computational tool to model key biomembrane phenomena like endocytosis,...
The National Science Foundation (NSF) awarded a $335,976 Project Grant under the Engineering CFDA Program (47.041) to the Regents of the University of California, Riverside (UC Riverside) for a 3-year period from October 1, 2023 to September 30, 2026. This grant will fund research to investigate the dynamics of particulate suspensions confined by flexible elastic membranes, which are common in biological micro-scale environments. The project aims to develop a fundamental understanding of the...
This $208,784 federal Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research project to study the emergent dynamics and scaling laws of bioinspired lipid membranes. The University of Arizona, as the primary awardee, will integrate experimental methods such as neutron spectroscopy, NMR, and flicker spectroscopy with molecular dynamics simulations. This integrated approach aims to establish the...
This Project Grant award, provided by the National Science Foundation's Engineering program (CFDA 47.041), supports research to quantify the mechanical forces within living cells and determine how changes in these forces impact cellular protein production and secretion. The $297,984 award, with a performance period from February 1, 2025 to January 31, 2028, will enable the University of Texas Health Science Center at Houston to develop a predictive model of intracellular stresses and gene...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $393,371 to the Texas A&M Engineering Experiment Station (Tees) to conduct research on the mechanics of the nuclear envelope (NE) - the physical barrier between the cytoplasm and the nucleus in eukaryotic cells. The overarching goals are to: 1) discover the link between NE structure and its mechanical properties, and 2) identify principles for designing new biologically-inspired...
This Project Grant from the National Science Foundation Division of Materials Research, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $333,827 to Brandeis University for research developing quantitative continuum theories of composite active fluids from September 1, 2022 through August 31, 2025. The research will develop theoretical and computational frameworks to describe the dynamics of multi-component biological and synthetic fluids containing self-powered...
The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
The National Science Foundation awarded a $255,760 Project Grant to Oregon State University under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The grant funds research by Professor Juan M. Vanegas at the University of Vermont on the mechanical behavior and response of cellular components to physical stimuli at the nanoscale. Using novel computational methods, Professor Vanegas develops molecular simulation tools to investigate lipid membrane elasticity in...