This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...
The National Science Foundation awarded a $179,150 Project Grant to the Donald Danforth Plant Science Center under the Biological Sciences federal grant program (CFDA 47.074) for the period of June 15, 2022 through May 31, 2024. The award will support the development of new computational tools and methods to translate single-cell RNA sequencing data into an ultra-high resolution 3D spatial map of gene expression in plant roots. Specifically, the grantee will leverage existing fluorescent...
This federal Project Grant award of $1,192,499.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research by the Donald Danforth Plant Science Center in Missouri to develop epigenetic editing tools for crop improvement. The key objectives of this 4-year project are to: 1) Expand epigenetic editing technologies to other crop species beyond cassava, such as rice and tomato, to enable disease resistance; 2) Demonstrate additional applications of...
This $1,150,000 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program supports the development and sharing of high-resolution in situ 3D cryo-imaging workflows to transform plant cell biology research. The award recipient, the Donald Danforth Plant Science Center, will use the funding to advance cryogenic preservation and nanoscale imaging techniques for visualizing the native structure of plant cells and organelles using volume...
This $699,870 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports the development of simplified and highly efficient genetic modification technologies for economically important grasses and cereal crops. The "PLANTTRANSFORM: SMART GRASS" project aims to overcome the current constraint in the plant science research community regarding the capacity to genetically modify major crop plants. The award establishes a...
This $959,997 federal Project Grant, awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074), supports collaborative research at the Cold Spring Harbor Laboratory to develop improved methods for plant transformation and regeneration. The research aims to provide a thorough understanding of the molecular mechanisms underlying regeneration in maize, a key crop that provides a substantial portion of human caloric intake. By exploiting a "morphogenic-based"...
This $998,790 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support enhancing global plant transformation capacity through research, training, and partnerships led by Boyce Thompson Institute For Plant Research Inc. Over a three-year period, the grantee will establish a global research coordination network to collectively address challenges to plant genetic engineering and gene editing efficiency. The network aims to facilitate collaboration,...
The National Science Foundation Division of Integrative Organismal Systems awarded a $206,320 Project Grant to the Donald Danforth Plant Science Center for the period of May 1, 2022 through April 30, 2023. The grant supports collaborative research to develop an artificial chromosome system in Chlamydomonas based on CENH3 tethering under the Biological Sciences program (CFDA 47.074). The Biological Sciences program aims to promote progress in the biological sciences and strengthen the nation's...
The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a 4-year, $2,670,305 Project Grant titled "TRTECH-PGR: REPROGRAMMING THE PLANT CELL WITH TRANSCRIPTION FACTORS" under the Biological Sciences federal grant program (CFDA 47.074). This project aims to systematically assess the effects of ectopically expressing thousands of maize transcription factors on gene expression and physiological responses in plant tissues. The research will use...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award, valued at $726,093 and spanning from April 1, 2025 to March 31, 2028, is funding research by the University of Washington to develop programmable and tunable regulatory elements for predictive gene expression in plants. The goals are to: Create a large repertoire of synthetic regulatory elements using massively parallel reporter assays, machine learning, and in silico evolution. Precisely control gene...