Project Grant 2138684
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation...
- This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
- The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $135,000 Project Grant to the University of Central Florida (UCF) for the project "COLLABORATIVE RESEARCH: EAGER: 3D BIOPRINTED ORGANOIDS FOR STUDYING THE MECHANISM OF CEREBROVASCULAR AGING". This award supports the development of 3D bioprinted cerebrovascular organoids derived from human induced pluripotent stem cells to study the impact of cellular senescence...
- This National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences project grant for $300,000 aims to engineer shape-morphing materials as cell sheet culturing substrates to develop human tissues with controllable shape, cellular composition, and morphology. The 3-year project, beginning on September 1, 2023, will use thermoresponsive hydrogels to enable cell sheet expulsion and explore how material characteristics impact stem cell fate. Additionally, the project seeks...
- This CAREER award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will provide $314,769 to the University of Delaware to support research advancing the fundamental understanding of how cells and tissue communicate information about their mechanical environment. The project aims to develop new material platforms based on magnetic materials that can dynamically change local tissue stiffness to mimic biological events and measure the resulting mechanobiological...
- This $483,492 Project Grant awarded by the National Science Foundation's Engineering program to the University of Maryland, College Park, aims to develop biomaterial tools for investigating how extracellular matrix (ECM) ligands influence the function of macrophage immune cells. The 5-year project will leverage polyethylene glycol-based biomaterials with known peptide-derived ECM ligands to quantify the impact of ECM ligand-integrin receptor interactions on macrophage activation. The research...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise...
- This National Science Foundation (NSF) Engineering Research Initiation (ERI) grant, award number 2347433, provides $200,000 in funding to Lafayette College to conduct fundamental research on the mechanical properties of ligaments and tendons. The goal is to better understand how these musculoskeletal tissues deform and fail by examining the mechanical behavior of the interfascicular matrix and fascicles that make up the tissue structure. The research team will use stereo digital image...
- This $200,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by New York University (NYU) School of Medicine. The project aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. Key objectives include: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing temperature-responsive fluorinated hydrogels,...
This $199,988 National Science Foundation Engineering Research Initiation award will support the development of a 3D in vitro model to study the relationship between changes in brain tissue extracellular matrix composition and neuroinflammation. Specifically, the awardee, Trinity University, will fabricate multi-interpenetrating polymer networks comprised of fibrin, hyaluronic acid, collagen, and polyethylene glycol to mimic key changes in matrix content and study their effect on human astrocyte reactivity and inflammatory response. The scaffolds will be made using a network-by-network fabrication approach with orthogonal crosslinking to control rigidity, stability, and cell morphology. This work will demonstrate the model's utility in uncovering connections between extracellular matrix remodeling and astrocyte inflammatory signaling. The award reflects the NSF's mission to advance engineering research and was deemed worthy through intellectual merit and broader impacts review. The award period is April 1, 2022 to March 31, 2024.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.0k | 1/28/22 |