This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This $314,769 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports research that aims to advance the fundamental understanding of how cells and tissues communicate information about their mechanical environment. The award, effective from February 1, 2025 to January 31, 2030, will fund the development of new material platforms based on magnetic materials that can dynamically change local stiffness via magnetic fields. Experiments will explore how...
This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $192,015 to Boise State University to conduct research aimed at quantifying the mechanical forces inside living cells and determining how changes in these forces impact cellular behavior and protein production. The overarching goal is to develop predictive models and technologies that can leverage mechanical forces to guide cellular differentiation and tissue regeneration, with potential...
This $380,500 National Science Foundation project grant supports collaborative research at the University of California, Los Angeles to analyze mechanosensitive channels in bacteria using force spectroscopy. The research team will utilize atomic force microscopy to observe the opening of single mechanosensitive channels in living bacteria in response to mechanical compression. This will help characterize how these channels function to protect bacteria from rupturing due to excessive internal...
This $297,984 federal Project Grant award, funded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports research to develop data-driven mechanomics approaches to uncover age-related mechanoregulation of bone-mesenchymal stem cells. The research aims to quantify the mechanical forces inside living cells and determine how changes in these forces impact the cells' production and secretion of proteins that shape their surrounding environment. This knowledge could...
This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
The University of California, Merced received a $200,000 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation on May 15, 2022 to support research under the Engineering program (CFDA 47.041). The award will fund research from May 15, 2022 through April 30, 2024 to develop multi-scale models of cell-matrix mechanical interactions during endothelial cell network assembly. The Engineering program seeks to improve quality of life and...
The University of California, Merced received a $750,000 National Science Foundation Project Grant under the Engineering program (CFDA 47.041) to support research titled "UNDERSTANDING THE DEFORMABILITY OF BIOLOGICAL FILAMENTS FROM THEIR ATOMISTIC LEVEL DETAILS" from January 1, 2022 through December 31, 2026. The grant will fund research examining the deformability of biological filaments through analysis of their atomic structure to gain a deeper understanding of their material...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to: Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions. Directly relate the observed domain unfolding of the...
The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded a $599,999 Project Grant to the University of California, San Diego to support research titled "BRITE PIVOT: MOLECULAR BASIS OF MECHANOTRANSDUCTION PROBED USING SOFT MATERIALS SCIENCE." The award period is from January 1, 2022 through December 31, 2024. The grant will fund research into the molecular basis of mechanotransduction using soft materials science approaches. Specifically,...