This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
This $995,498 National Science Foundation project grant supports research at the University of California, Los Angeles to advance knowledge of cellular mechanobiology and translate findings for sustainable protein production. Funded through the NSF's Engineering program (CFDA 47.041), the research aims to understand how cells sense and respond to mechanical stimuli by building a systems-level understanding of the "mechanome." Specific goals include investigating predicted mechanical...
The National Science Foundation awarded a $548,102 project grant under the Engineering (47.041) program to the University of Texas at Austin to develop a predictive framework for understanding how bacteria sense and respond to surface mechanics upon attachment. The three-year award beginning April 1, 2022 will support research using atomic force microscopy, high-throughput culturing, finite element modeling, quantitative confocal microscopy, and genetic manipulation to characterize the stresses,...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $139,341 project grant to the Regents of the University of California, San Francisco (UCSF) under the NSF Biological Sciences program (CFDA 47.074). The 3-year grant, effective August 1, 2023, supports collaborative research to investigate the biomechanical mechanisms underlying wound resilience in the single-celled organism Stentor coeruleus. The research will leverage cell biology, microfluidics, and...
This National Science Foundation Project Grant award of $997,716 provides funding from May 15, 2022 through April 30, 2026 to investigate the molecular mechanisms that maintain the integrity of the bacterial cell envelope under stress conditions. The award was made under the Biological Sciences program (CFDA 47.074) to the Research Foundation of the City University of New York at the City College of New York. Specifically, the awardee will examine how bacteria regulate the post-translational...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $373,168 supports collaborative research between the University of Wisconsin-Milwaukee and Northeastern Illinois University to understand the molecular mechanisms behind how myxobacteria use phytochromes to sense light and convert that signal into developmental changes, such as fruiting body formation. The research will utilize cutting-edge techniques including time-resolved X-ray...
The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded a $599,999 Project Grant to the University of California, San Diego to support research titled "BRITE PIVOT: MOLECULAR BASIS OF MECHANOTRANSDUCTION PROBED USING SOFT MATERIALS SCIENCE." The award period is from January 1, 2022 through December 31, 2024. The grant will fund research into the molecular basis of mechanotransduction using soft materials science approaches. Specifically,...